Kidney injury molecule-1

被引：80

作者：

Bonventre, Joseph V. ^{[1
,2
]}

Yang, Li ^{[2
,3
]}

机构：

[1] Brigham & Womens Hosp, Harvard Inst Med, Div Renal, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Med, Boston, MA USA

[3] Peking Univ, Hosp 1, Div Renal, Beijing 100871, Peoples R China

来源：

CURRENT OPINION IN CRITICAL CARE | 2010年 / 16卷 / 06期

关键词：

acute kidney injury; kidney injury molecule-1; urinary biomarker; BIOMARKER QUALIFICATION; URINARY BIOMARKERS; EMERGING ROLE; RENAL INJURY; NEPHROTOXICITY; TRANSPLANTATION; EXPRESSION; TOLERANCE; TOXICITY; PROTEIN;

D O I：

10.1097/MCC.0b013e32834008d3

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Purpose of review To review the new findings about the physiological roles of kidney injury molecule-1 (KIM-1) and the rapidly expanding evidence for this molecule as a promising biomarker in preclinical kidney toxicity evaluation and various human kidney diseases. Recent findings KIM-1 has attracted increasing interest because of its possible pathophysiological role in modulating tubular damage and repair. There is rapidly accumulating evidence from both animal models and clinical studies that urinary KIM-1 is a sensitive and specific urinary biomarker for various forms of nephrotoxic injury, cardiac surgery-induced kidney injury, transplant rejection, and chronic kidney diseases. Summary KIM-1 mediates epithelial phagocytosis in the injured kidney converting the proximal epithelial cell into a phagocyte, with potentially important pathophysiological implications for modulation of the immune response and repair process after injury. KIM-1 serves as a highly sensitive and specific urinary biomarker for kidney injury and may also be a therapeutic target for various kidney diseases.

引用

页码：556 / 561

页数：6

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