Regioselective oxidation of steroids by a manganese porphyrin carrying metal coordinating groups

被引：28

作者：

Belvedere, S ^{[1
]}

Breslow, R ^{[1
]}

机构：

[1] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

BIOORGANIC CHEMISTRY | 2001年 / 29卷 / 05期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

steroid oxidation; metal coordination; cytochrome P450; enzyme mimics;

D O I：

10.1006/bioo.2001.1215

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A manganese porphyrin having four 2,2'-bipyridyl groups on its meso positions was synthesized. In the presence of Cu2+ ions it catalyzes the regioselective oxidation of steroid substrates carrying auxiliary metal coordinating goups. (C) 2001 Academic Press.

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收藏

页码：321 / 331

页数：11

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