Solid state characteristics of ternary solid dispersions composed of PVPVA64, Myrj 52 and itraconazole

被引：70

作者：

Wang, X ^{[1
]}

Michoel, A ^{[1
]}

Van den Mooter, G ^{[1
]}

机构：

[1] Catholic Univ Louvain, Fac Farmaceut Wetenschappen, Lab Farmacotechnol & Biofarm, B-3000 Louvain, Belgium

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2005年 / 303卷 / 1-2期

关键词：

PVPVA; 64; Myrj; 52; itraconazole; MTDSC; X-ray powder diffraction; solid dispersions;

D O I：

10.1016/j.ijpharm.2005.07.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The purpose of the present study was to characterize the solid state properties of ternary solid dispersions made up of PVP VA64, Myrj 52 and itraconazole. The solid dispersions were prepared by dissolving the materials in methylene chloride, followed by evaporation under reduced pressure of the solvent at 55 degrees C in a rotovapor. Binary and ternary solid dispersions were characterized by standard and modulated temperature differential scanning calorimetry and X-ray powder diffraction. Although PVP VA64 and itraconazole were found to be completely miscible in the solid state, addition of a small amount of Myrj 52 to the drug-polymer system leads to separation of itraconazole thus demonstrating that Myrj 52 expels the drug from the polymer phase. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：54 / 61

页数：8

共 14 条

[11] Increased physical stability and improved dissolution properties of itraconazole, a class II drug, by solid dispersions that combine fast- and slow-dissolving polymers [J].