rTMS of supplementary motor area modulates therapy-induced dyskinesias in Parkinson disease

被引：127

作者：

Koch, G

Brusa, L

Caltagirone, C

Peppe, A

Oliveri, M

Stanzione, P

Centonze, D

机构：

[1] Fdn Santa Lucia, IRCCS, Lab Neurol Clin & Comportamentale, I-00179 Rome, Italy

[2] Univ Roma Tor Vergata, Dipartimento Neurosci, Rome, Italy

[3] Univ Palermo, Dipartimento Psicol, Palermo, Italy

来源：

NEUROLOGY | 2005年 / 65卷 / 04期

关键词：

D O I：

10.1212/01.wnl.0000172861.36430.95

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The neural mechanisms and circuitry involved in levodopa-induced dyskinesia are unclear. Using repetitive transcranial magnetic stimulation (rTMS) over the supplementary motor area (SMA) in a group of patients with advanced Parkinson disease, the authors investigated whether modulation of SMA excitability may result in a modification of a dyskinetic state induced by continuous apomorphine infusion. rTMS at 1 Hz was observed to markedly reduce drug-induced dyskinesias, whereas 5-Hz rTMS induced a slight but not significant increase.

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收藏

页码：623 / 625

页数：3

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