Phenolic glycosides from Dodecadenia grandiflora and their glucose-6-phosphatase inhibitory activity

被引：20

作者：

Kumar, Manmeet ^{[1
]}

Rawat, Preeti ^{[1
]}

Khan, Mohammad Faheem ^{[1
]}

Tamarkar, Akhilesh K. ^{[2
]}

Srivastava, Arvind K. ^{[2
]}

Arya, Kama R. ^{[3
]}

Maurya, Rakesh ^{[1
]}

机构：

[1] CSIR, Cent Drug Res Inst, Med & Proc Chem Div, Lucknow 226001, Uttar Pradesh, India

[2] CSIR, Cent Drug Res Inst, Div Biochem, Lucknow 226001, Uttar Pradesh, India

[3] CSIR, Cent Drug Res Inst, Bot Div, Lucknow 226001, Uttar Pradesh, India

来源：

FITOTERAPIA | 2010年 / 81卷 / 06期

关键词：

Dodecadenia grandiflora; Glucose-6-phosphatase; Phenolic glycoside; Coumaroyl; ESTERS; ACID;

D O I：

10.1016/j.fitote.2010.01.011

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Phytochemical investigation of Dodecadenia grandiflora leaves led to the isolation and identification of three phenolic glycosides, designated 1-[(4'-O-(E)-p-coumaroyl)-beta-D-glucopyranosyl]-oxy-2-phenol (1), 1-[(6'-O-(E)-p-coumaroyl)-beta-D-glucopyranosyl]-oxy-2-phenol (2) and 1-[O-beta-D-glucopyranosyl(1 -> 2)-beta-D-glucopyranosyl]-oxy-2-phenol (3), along with nine known compounds. Compounds 1, 2, 5 and 9 exhibited significant glucose-6-phosphatase inhibitory activity (63.7, 66.9, 82.9 and 85.4%) with IC50 values of 88.5, 81.0, 51 and 50 mu M respectively. On the basis of biological results, a structure-activity relationship has been discussed. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：475 / 479

页数：5

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