Tubeimoside I protects against sepsis-induced cardiac dysfunction via SIRT3

被引：23

作者：

Cheng, Zhe ^{[1
,2
]}

Lv, Dingyi ^{[1
,2
]}

Luo, Minghao ^{[1
,2
]}

Wang, Ruiyu ^{[1
,2
]}

Guo, Yongzheng ^{[1
,2
]}

Yang, Xiyang ^{[1
,2
]}

Huang, Longxiang ^{[1
,2
]}

Li, Xingbing ^{[1
,2
]}

Li, Chang ^{[1
,2
]}

Shang, Fei-Fei ^{[2
]}

Huang, Bi ^{[1
]}

Shen, Jian ^{[1
,2
]}

Luo, Suxin ^{[1
,2
]}

Yan, Jianghong ^{[2
]}

机构：

[1] Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiol, Chongqing 400010, Peoples R China

[2] Chongqing Med Univ, Inst Life Sci, Chongqing 400010, Peoples R China

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2021年 / 905卷

基金：

中国国家自然科学基金;

关键词：

Sepsis-induced cardiac dysfunction (SICD); Tubeimoside I; SIRT3; Inflammation; Oxidative stress; Apoptosis; DIASTOLIC DYSFUNCTION; OXIDATIVE STRESS; SEPTIC SHOCK; MORTALITY; PREVENTION; CARDIOMYOPATHY; DEACETYLASE; METABOLISM; INJURY; CELLS;

D O I：

10.1016/j.ejphar.2021.174186

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Sepsis-induced cardiac dysfunction (SICD) is one of the key complications in sepsis and it is associated with adverse outcomes and increased mortality. There is no effective drug to treat SICD. Previously, we reported that tubeimoside I (TBM) improved survival of septic mice. The aim of this study is to figure out whether TBM ameliorates SICD. Also, SIRT3 was reported to protects against SICD. Our second aim is to confirm whether SIRT3 plays essential roles in TBM's protective effects against SICD. Our results demonstrated that TBM could alleviate SICD and SICD's key pathological factor, inflammation, oxidative stress, and apoptosis were all reduced by TBM. Notably, SICD induced a significant decrease in cardiac SIRT3 expression, while TBM treatment could reverse SIRT3 expression. To clarify whether TBM provides protection via SIRT3, we injected a specific SIRT3 inhibitor 3-(1H-1,2,3-triazol-4-yl) pyridine (3-TYP) into mice before TBM treatment. Then the cardioprotective effects of TBM were largely abolished by 3-TYP. This suggests that SIRT3 plays an essential role in TBM's cardioprotective effects. In vitro, TBM also protected H9c2 cells against LPS-induced injury, and siSIRT3 diminished these protective effects. Taken together, our results demonstrate that TBM protects against SICD via SIRT3. TBM might be a potential drug candidate for SICD treatment.

引用

页数：12

共 59 条

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