Radiation-induced formation of a crosslink between base moieties of deoxyguanosine and thymidine in deoxygenated solutions of d(CpGpTpA)

被引：63

作者：

Box, HC

Budzinski, EE

Dawidzik, JD

Wallace, JC

Evans, MS

Gobey, JS

机构：

[1] Biophysics Department, Roswell Park Cancer Institute, Buffalo

来源：

RADIATION RESEARCH | 1996年 / 145卷 / 05期

关键词：

D O I：

10.2307/3579285

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A new type of tandem base lesion has been observed in d(CpGpTpA) X-irradiated in aqueous solution. The lesion is attributed to the formation of a covalent bond between the C8 carbon atom of guanine and the methyl carbon atom of thymine. This tandem base lesion is formed in the absence of oxygen. It is the main product produced by ionizing radiation under these conditions. (C) 1996 by Radiation Research

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页码：641 / 643

页数：3

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