Genetics of aging in Caenorhabditis elegans

被引:150
作者
Antebi, Adam
机构
[1] Huffington Center on Aging, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX
来源
PLOS GENETICS | 2007年 / 3卷 / 09期
关键词
D O I
10.1371/journal.pgen.0030129
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
A dissection of longevity in Caenorhabditis elegans reveals that animal life span is influenced by genes, environment, and stochastic factors. From molecules to physiology, a remarkable degree of evolutionary conservation is seen. © 2007 Adam Antebi.
引用
收藏
页码:1565 / 1571
页数:7
相关论文
共 132 条
[61]   The plasticity of aging: Insights from long-lived mutants [J].
Kenyon, C .
CELL, 2005, 120 (04) :449-460
[62]   A C-ELEGANS MUTANT THAT LIVES TWICE AS LONG AS WILD-TYPE [J].
KENYON, C ;
CHANG, J ;
GENSCH, E ;
RUDNER, A ;
TABTIANG, R .
NATURE, 1993, 366 (6454) :461-464
[63]   daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans [J].
Kimura, KD ;
Tissenbaum, HA ;
Liu, YX ;
Ruvkun, G .
SCIENCE, 1997, 277 (5328) :942-946
[64]   AGING IN NEMATODE CAENORHABDITIS-ELEGANS - MAJOR BIOLOGICAL AND ENVIRONMENTAL-FACTORS INFLUENCING LIFE-SPAN [J].
KLASS, MR .
MECHANISMS OF AGEING AND DEVELOPMENT, 1977, 6 (06) :413-429
[65]   The genetics of caloric restriction in Caenorhabditis elegans [J].
Lakowski, B ;
Hekimi, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (22) :13091-13096
[66]   Determination of life-span in Caenorhabditis elegans by four clock genes [J].
Lakowski, B ;
Hekimi, S .
SCIENCE, 1996, 272 (5264) :1010-1013
[67]   Multiple sensory G proteins in the olfactory gustatory and nociceptive neurons modulate longevity in Caenorhabditis elegans [J].
Lans, Hannes ;
Jansen, Gert .
DEVELOPMENTAL BIOLOGY, 2007, 303 (02) :474-482
[68]   Dietary deprivation extends lifespan in Caenorhabditis elegans [J].
Lee, Garrick D. ;
Wilson, Mark A. ;
Zhu, Min ;
Wolkow, Catherine A. ;
de Cabo, Rafael ;
Ingram, Donald K. ;
Zou, Sige .
AGING CELL, 2006, 5 (06) :515-524
[69]   THE C-ELEGANS HETEROCHRONIC GENE LIN-4 ENCODES SMALL RNAS WITH ANTISENSE COMPLEMENTARITY TO LIN-14 [J].
LEE, RC ;
FEINBAUM, RL ;
AMBROS, V .
CELL, 1993, 75 (05) :843-854
[70]   Regulation of C-elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway [J].
Lee, RYN ;
Hench, J ;
Ruvkun, G .
CURRENT BIOLOGY, 2001, 11 (24) :1950-1957