Sex hormones and autoimmunity

被引：125

作者：

Almeida Gonzalez, Delia ^{[2
]}

Brito Diaz, Buenaventura

Rodriguez Perez, Maria del Cristo

Gonzalez Hernandez, Ana ^{[3
]}

Diaz Chico, B. Nicolas ^{[3
,4
]}

Cabrera de Leon, Antonio ^{[1
,3
,5
]}

机构：

[1] Hosp Univ NS Candelaria, Unidad Invest, Santa Cruz de Tenerife 38010, Spain

[2] Univ Hosp Nuestra Senora Candelaria, Immunol Unit, Tenerife, Spain

[3] Canary Isl Canc Res Inst, Las Palmas Gran Canaria, Spain

[4] Univ Las Palmas Gran Canaria, Dept Physiol, Las Palmas Gran Canaria, Spain

[5] Univ La Laguna, Dept Prevent Med & Publ Hlth, E-38207 San Cristobal la Laguna, Spain

来源：

IMMUNOLOGY LETTERS | 2010年 / 133卷 / 01期

关键词：

Autoimmune diseases; Sex hormones; Th1/Th2; balance; Cytokines; Systemic lupus erythematosus; BLOOD MONONUCLEAR-CELLS; TUMOR-NECROSIS-FACTOR; NORMAL PREGNANT SUBJECTS; PERIPHERAL-BLOOD; CYTOKINE PRODUCTION; IMMUNE-RESPONSE; RHEUMATOID-ARTHRITIS; GENDER-DIFFERENCES; LUTEAL-PHASE; B-CELL;

D O I：

10.1016/j.imlet.2010.07.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoimmune diseases occur more in women than in men, and this may be attributable to the role of estrogens. Androgens promote autoimmune diseases with a profile of type 1 cytokines, such as rheumatoid arthritis, whereas estrogens promote autoimmune diseases with a type 2 cytokine profile, like systemic lupus erythematosus. Both androgens and estrogens regulate the Th1/Th2 balance. Type 1 autoimmune diseases are improved when decrease type 1 cytokines (i.e. during fasting), or when there is a rise in type 2 cytokines (increased estrogens, as in pregnancy). Type 2 autoimmune diseases improve when type 2 cytokines are diminished (decreased estrogen, as in post-partum period) or when type 1 response is stimulated. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：6 / 13

页数：8

共 145 条

[11] Influence of low-dose oral contraception on peripheral blood lymphocyte subsets at particular phases of the hormonal cycle
Auerbach, L
Hafner, T
Huber, JC
Panzer, S
[J]. FERTILITY AND STERILITY, 2002, 78 (01) : 83 - 89
[12] VARIATIONS IN LEUKOCYTE COUNT DURING MENSTRUAL-CYCLE
BAIN, BJ
ENGLAND, JM
[J]. BRITISH MEDICAL JOURNAL, 1975, 2 (5969) : 473 - 475
[13] Transcriptional regulation of the human 'leukemia inhibitory factor' gene: Modulation by glucocorticoids and estradiol
Bamberger, AM
Erdmann, I
Bamberger, CM
Jenatschke, SS
Schulte, HM
[J]. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1997, 127 (01) : 71 - 79
[14] Regulation of innate and adaptive immunity by the female sex hormones oestradiol and progesterone
Beagley, KW
Gockel, CM
[J]. FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 2003, 38 (01): : 13 - 22
[15] Steroid hormone receptors: an update
Beato, M
Klug, J
[J]. HUMAN REPRODUCTION UPDATE, 2000, 6 (03) : 225 - 236
[16] In vitro effects of different steroid hormones on superoxide anion production of human neutrophil granulocytes
Békési, G
Kakucs, R
Várbíró, S
Rácz, K
Sprintz, D
Fehér, J
Székács, B
[J]. STEROIDS, 2000, 65 (12) : 889 - 894
[17] MENOPAUSE IS ASSOCIATED WITH A SIGNIFICANT INCREASE IN BLOOD MONOCYTE NUMBER AND A RELATIVE DECREASE IN THE EXPRESSION OF ESTROGEN-RECEPTORS IN HUMAN PERIPHERAL MONOCYTES
BENHUR, H
MOR, G
INSLER, V
BLICKSTEIN, I
AMIRZALTSMAN, Y
SHARP, A
GLOBERSON, A
KOHEN, F
[J]. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 1995, 34 (06): : 363 - 369
[18] B cells express intracellular but not surface receptors for testosterone and estradiol
Benten, WPM
Stephan, C
Wunderlich, F
[J]. STEROIDS, 2002, 67 (07) : 647 - 654
[19] Estradiol binding to cell surface raises cytosolic free calcium in T cells
Benten, WPM
Lieberherr, M
Giese, G
Wunderlich, F
[J]. FEBS LETTERS, 1998, 422 (03) : 349 - 353
[20] HUMORAL IMMUNITY IN ORAL-CONTRACEPTIVE USERS .2. INVITRO IMMUNOGLOBULIN PRODUCTION
BISSET, LR
GRIFFIN, JFT
[J]. CONTRACEPTION, 1988, 38 (05) : 573 - 578

← 1 2 3 4 5 6 7 8 9 10 →