New views of Arc, a master regulator of synaptic plasticity

被引：373

作者：

Shepherd, Jason D. ^{[1
]}

Bear, Mark F.

机构：

[1] MIT, Dept Brain & Cognit Sci, Picower Inst Learning & Memory, Cambridge, MA 02139 USA

来源：

NATURE NEUROSCIENCE | 2011年 / 14卷 / 03期

关键词：

LONG-TERM POTENTIATION; IMMEDIATE-EARLY GENE; OCULAR DOMINANCE PLASTICITY; MOUSE VISUAL-CORTEX; AMPA RECEPTOR TRAFFICKING; MESSENGER-RNA; PROTEIN EXPRESSION; MEMORY CONSOLIDATION; ANGELMAN SYNDROME; DENDRITIC SPINE;

D O I：

10.1038/nn.2708

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Many proteins have been implicated in synaptic and experience-dependent plasticity. However, few demonstrate the exquisite regulation of expression and breadth of functional importance as the immediate early gene product Arc. Here we review and attempt to synthesize the disparate views of Arc in neuronal function. The main conclusion garnered from this body of work is that Arc is a critical effector molecule downstream of many molecular signaling pathways and that dysregulation of Arc expression can have dire consequences for normal brain function.

引用

页码：279 / 284

页数：6

共 50 条

[1] NMDA receptor-independent control of transcription factors and gene expression [J].

Adams, J. Paige ;

Robinson, Rachel A. ;

Hudgins, Eric D. ;

Wissink, Erin M. ;

Dudek, Serena M. .

NEUROREPORT, 2009, 20 (16) :1429-1433

[2] THEORY FOR THE DEVELOPMENT OF NEURON SELECTIVITY - ORIENTATION SPECIFICITY AND BINOCULAR INTERACTION IN VISUAL-CORTEX [J].

BIENENSTOCK, EL ;

COOPER, LN ;

MUNRO, PW .

JOURNAL OF NEUROSCIENCE, 1982, 2 (01) :32-48

[3] The Immediate Early Gene Arc/Arg3.1: Regulation, Mechanisms, and Function [J].

Bramham, Clive R. ;

Worley, Paul F. ;

Moore, Melissa J. ;

Guzowski, John F. .

JOURNAL OF NEUROSCIENCE, 2008, 28 (46) :11760-11767

[4] Amyloid-β Interrupts the PI3K-Akt-mTOR Signaling Pathway That Could Be Involved in Brain-Derived Neurotrophic Factor-Induced Arc Expression in Rat Cortical Neurons [J].

Chen, Tsan-Ju ;

Wang, Dean-Chuan ;

Chen, Shun-Sheng .

JOURNAL OF NEUROSCIENCE RESEARCH, 2009, 87 (10) :2297-2307

[5] The ratio of NR2A/B NMDA receptor subunits determines the qualities of ocular dominance plasticity in visual cortex [J].

Cho, Kathleen K. A. ;

Khibnik, Lena ;

Philpot, Benjamin D. ;

Bear, Mark F. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (13) :5377-5382

[6] Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking [J].

Chowdhury, Shoaib ;

Shepherd, Jason D. ;

Okuno, Hiroyuki ;

Lyford, Gregory ;

Petralia, Ronald S. ;

Plath, Niels ;

Kuhl, Dietmar ;

Huganir, Richard L. ;

Worley, Paul F. .

NEURON, 2006, 52 (03) :445-459

[7] PROTEIN-SYNTHESIS AND MEMORY - A REVIEW [J].

DAVIS, HP ;

SQUIRE, LR .

PSYCHOLOGICAL BULLETIN, 1984, 96 (03) :518-559

[8] Amyloid suppresses induction of genes critical for memory consolidation in APP+PS1 transgenic mice [J].

Dickey, CA ;

Gordon, MN ;

Mason, JE ;

Wilson, NJ ;

Diamond, DM ;

Guzowski, JF ;

Morgan, D .

JOURNAL OF NEUROCHEMISTRY, 2004, 88 (02) :434-442

[9] Instructive effect of visual experience in mouse visual cortex [J].

Frenkel, Mikhail Y. ;

Sawtell, Nathaniel B. ;

Diogo, Antonia Cinira M. ;

Yoon, Bongjune ;

Neve, Rachael L. ;

Bear, Mark F. .

NEURON, 2006, 51 (03) :339-349

[10] Synaptic tagging and long-term potentiation [J].

Frey, U ;

Morris, RGM .

NATURE, 1997, 385 (6616) :533-536

← 1 2 3 4 5 →