New views of Arc, a master regulator of synaptic plasticity

被引：373

作者：

Shepherd, Jason D. ^{[1
]}

Bear, Mark F.

机构：

[1] MIT, Dept Brain & Cognit Sci, Picower Inst Learning & Memory, Cambridge, MA 02139 USA

来源：

NATURE NEUROSCIENCE | 2011年 / 14卷 / 03期

关键词：

LONG-TERM POTENTIATION; IMMEDIATE-EARLY GENE; OCULAR DOMINANCE PLASTICITY; MOUSE VISUAL-CORTEX; AMPA RECEPTOR TRAFFICKING; MESSENGER-RNA; PROTEIN EXPRESSION; MEMORY CONSOLIDATION; ANGELMAN SYNDROME; DENDRITIC SPINE;

D O I：

10.1038/nn.2708

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Many proteins have been implicated in synaptic and experience-dependent plasticity. However, few demonstrate the exquisite regulation of expression and breadth of functional importance as the immediate early gene product Arc. Here we review and attempt to synthesize the disparate views of Arc in neuronal function. The main conclusion garnered from this body of work is that Arc is a critical effector molecule downstream of many molecular signaling pathways and that dysregulation of Arc expression can have dire consequences for normal brain function.

引用

页码：279 / 284

页数：6

共 50 条

[41] Dendritic protein synthesis, synaptic plasticity, and memory [J].

Sutton, Michael A. ;

Schuman, Erin M. .

CELL, 2006, 127 (01) :49-58

[42] Multiple periods of functional ocular dominance plasticity in mouse visual cortex [J].

Tagawa, Y ;

Kanold, PO ;

Majdan, M ;

Shatz, CJ .

NATURE NEUROSCIENCE, 2005, 8 (03) :380-388

[43] The Self-Tuning Neuron: Synaptic Scaling of Excitatory Synapses [J].

Turrigiano, Gina G. .

CELL, 2008, 135 (03) :422-435

[44] Arc/Arg3.1: Linking gene expression to synaptic plasticity and memory [J].

Tzingounis, Anastassios V. ;

Nicoll, Roger A. .

NEURON, 2006, 52 (03) :403-407

[45] Spatial exploration induces ARC, a plasticity-related immediate-early gene, only in calcium/calmodulin-dependent protein kinase II-positive principal excitatory and inhibitory neurons of the rat forebrain [J].

Vazdarjanova, Almira ;

Ramirez-Amaya, Victor ;

Insel, Nathan ;

Plummer, Thane K. ;

Rosi, Susanna ;

Chowdhury, Shoaib ;

Mikhael, Dalia ;

Worley, Paul F. ;

Guzowski, John F. ;

Barnes, Carol A. .

JOURNAL OF COMPARATIVE NEUROLOGY, 2006, 498 (03) :317-329

[46] β-amyloid modulation of synaptic transmission and plasticity [J].

Venkitaramani, Deepa V. ;

Chin, Jeannie ;

Netzer, William J. ;

Gouras, Gunnar K. ;

Lesne, Sylvain ;

Malinow, Roberto ;

Lombroso, Paul J. .

JOURNAL OF NEUROSCIENCE, 2007, 27 (44) :11832-11837

[47] Arg3.1/Arc mRNA induction by Ca2+ and cAMP requires protein kinase A and mitogen-activated protein kinase/extracellular regulated kinase activation [J].

Waltereit, R ;

Dammermann, B ;

Wulff, P ;

Scafidi, J ;

Staubli, U ;

Kauselmann, G ;

Bundman, M ;

Kuhl, D .

JOURNAL OF NEUROSCIENCE, 2001, 21 (15) :5484-5493

[48] Rapid translation of Arc/Arg3.1 selectively mediates mGluR-dependent LTD through persistent increases in AMPAR endocytosis rate [J].

Waung, Maggie W. ;

Pfeiffer, Brad E. ;

Nosyreva, Elena D. ;

Ronesi, Jennifer A. ;

Huber, Kimberly M. .

NEURON, 2008, 59 (01) :84-97

[49] Learning induces long-term potentiation in the hippocampus [J].

Whitlock, Jonathan R. ;

Heynen, Arnold J. ;

Shuler, Marshall G. ;

Bear, Mark F. .

SCIENCE, 2006, 313 (5790) :1093-1097

[50] Ube3a is required for experience-dependent maturation of the neocortex [J].

Yashiro, Koji ;

Riday, Thorfinn T. ;

Condon, Kathryn H. ;

Roberts, Adam C. ;

Bernardo, Danilo R. ;

Prakash, Rohit ;

Weinberg, Richard J. ;

Ehlers, Michael D. ;

Philpot, Benjamin D. .

NATURE NEUROSCIENCE, 2009, 12 (06) :777-U132

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