Smoking and female infertility: a systematic review and meta-analysis

被引:269
作者
Augood, C
Duckitt, K
Templeton, AA
机构
[1] Royal Coll Obstetricians & Gynaecologists, London NW1 4RG, England
[2] Aberdeen Matern Hosp, Dept Obstet & Gynaecol, Aberdeen AB25 2ZN, Scotland
关键词
infertility; in-vitro fertilization; meta-analysis; smoking; systematic review;
D O I
10.1093/humrep/13.6.1532
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
The high prevalence of smoking among women in their reproductive years continues to be a matter of concern, The negative effects of smoking on general health are well known, but smoking may also affect fertility. The objective of the present study was to perform a systematic review of the literature to determine whether there is an association between smoking and risk of infertility in women of reproductive age, and to assess the size of this effect. In the 12 studies used for this mete-analysis, the overall value of the odds ratio (OR) for risk of infertility in women smokers versus non-smokers was 1.60 [95% confidence interval (CI) 1.34-1.91]. Studies of subfertile women undergoing in-vitro fertilization (IVF) treatment also show a reduction in fecundity among women smokers. A metaanalysis of nine studies found an OR of 0.66 (95% CI 0.49-0.88) for pregnancies per number of IVF-treated cycles in smokers versus non-smokers. Despite the potential limitations of meta-analyses of observational studies, the evidence presented in this review is compelling because of the consistency of effect across different study designs, sample size and types of outcome. However, continued reassurance is needed that the calculated overall effect is not in fact due to confounding variables.
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页码:1532 / 1539
页数:8
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