The genetics of pancreatic adenocarcinoma: a roadmap for a mouse model

被引：26

作者：

Bardeesy, N ^{[1
]}

Sharpless, NE

DePinho, RA

Merlino, G

机构：

[1] Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Med & Genet, Boston, MA 02115 USA

[3] NCI, Mol Biol Lab, Bethesda, MD 20892 USA

来源：

SEMINARS IN CANCER BIOLOGY | 2001年 / 11卷 / 03期

关键词：

pancreatic cancer; transgenic mouse; genetics;

D O I：

10.1006/scbi.2000.0371

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic cancer is among the leading causes of cancer death. Although a genetic profile for pancreatic cancer is emerging, many biological aspects of this disease are poorly understood. Indeed fundamental questions regarding progenitor cell lineages, host stromal milieu, and the role of specific genetic alterations in tumor progression remain unresolved. A mouse model engineered with signature mutations would provide a powerful ally in the study of pancreatic cancer biology and may guide improved prognostic assessment and treatment for the human disease. In this review, we discuss the molecular basis for normal pancreatic development and the genetics of human pancreatic adenocarcinoma in the hope of charting a course for the development of a faithful mouse model for this lethal cancer.

引用

页码：201 / 218

页数：18

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