Ring-closing olefin metathesis for the synthesis of 1,8-diazabicyclo[4.3.0]non-3-ene-7,9-diones

被引：29

作者：

Dyatkin, AB ^{[1
]}

机构：

[1] BOEHRINGER INGELHEIM PHARMACEUT INC,DEPT CHEM DEV,RIDGEFIELD,CT 06877

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 12期

关键词：

ISOCYANATES; ACIDS;

D O I：

10.1016/S0040-4039(97)00286-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel method for the efficient synthesis of 1,8-diazabicyclo[4.3.0]non-3-ene-7,9-diones 5 (bicyclic hydantoins) starting from ureas or Z-protected aminoacids has been developed. The key step is a ring-closing metathesis (RCM) reaction of diallyl substituted hydantoins 3 catalyzed by the ruthenium-carbene complex bis(tricyclohexylphosphine)benzilidine ruthenium dichloride (4). (C) 1997 Elsevier Science Ltd.

引用

页码：2065 / 2066

页数：2

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