Syntheses and preventive effects of analogues related to 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (ED-71) on bone mineral loss in ovariectomized rats

被引：36

作者：

Ono, Y

Kawase, A

Watanabe, H

Shiraishi, A

Takeda, S

Higuchi, Y

Sato, K

Yamauchi, T

Mikami, T

Kato, M

Tsugawa, N

Okano, T

Kubodera, N

机构：

[1] Chugai Pharmaceut Co Ltd, Chuo Ku, Tokyo 1048301, Japan

[2] Kobe Pharmaceut Univ, Dept Hyg Sci, Kobe, Hyogo 6580003, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1998年 / 6卷 / 12期

关键词：

D O I：

10.1016/S0968-0896(98)80025-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Analogues related to 1 alpha,25-dihydroxy-2 beta-(3-hydroxypropoxy)vitamin D-3 (ED-71) (2), 26,27-dimethyl ED-71 (3) and 26,27-diethyl ED-71 (4), were synthesized from lithocholic acid (5). In the study of the preventive effects of these analogues and ED-71 (2) on bone mineral loss in ovariectomized rats, 26,27-dimethyl ED-71 (3) showed the most potent activity. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：2517 / 2523

页数：7

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