Sequence-based identification of specific drug target regions in the thymidylate synthase enzyme family

被引：15

作者：

Ferrari, Stefania ^{[1
]}

Losasso, Valeria ^{[1
]}

Costi, Maria Paola ^{[1
]}

机构：

[1] Univ Modena & Reggio Emilia, Dipartimento Sci Farmaceut, I-41100 Modena, Italy

来源：

CHEMMEDCHEM | 2008年 / 3卷 / 03期

关键词：

drug discovery; drug targets; sequence analysis specificity; thymidylate synthases;

D O I：

10.1002/cmdc.200700215

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

(Graph Presented) Thymidylate synthases from pathogenic organisms: Sequence analysis and knowledge-based grouping have provided a step forward in the identification of potential drug target regions in thymidylate synthases. This provides a unique approach toward blocking the growth of pathogenic organisms. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：392 / 401

页数：10

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