Delayed-type hypersensitivity responses to ESAT-6 and MPT64 from Mycobacterium tuberculosis in the guinea pig

被引：92

作者：

Elhay, MJ ^{[1
]}

Oettinger, T ^{[1
]}

Andersen, P ^{[1
]}

机构：

[1] Statens Serum Inst, Dept TB Immunol, DK-2300 Copenhagen S, Denmark

来源：

INFECTION AND IMMUNITY | 1998年 / 66卷 / 07期

关键词：

D O I：

10.1128/IAI.66.7.3454-3456.1998

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Two antigens from Mycobacterium tuberculosis, ESAT-6 and MPT64, elicited delayed-type hypersensitivity (DTH) skin responses in outbred guinea pigs infected with ill. tuberculosis by the aerosol and intravenous routes but not those sensitized nifh M. bovis BCG or M. avium. The DTH epitope of ESAT-6 was mapped to the C terminus. Nonresponders to the individual antigens were found, but all animals responded to a combination of ESAT-6 and MPT64 or their respective minimal target peptides. Correspondingly, these molecules could form the basis of a new skin test for tuberculosis.

引用

页码：3454 / 3456

页数：3

共 22 条

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