Difference in toxicity of β-amyloid peptide with aging in relation to nerve growth factor content in rat brain

被引：12

作者：

Fukuta, T

Nitta, A

Itoh, A

Furukawa, S

Nabeshima, T ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Neuropsychopharmacol & Hosp Pharm, Showa Ku, Nagoya, Aichi 466560, Japan

[2] Gifu Pharmaceut Univ, Mol Biol Lab, Gifu, Japan

[3] Eisai & Co Ltd, Drug Safety & Disposit Res Labs, Gifu, Japan

来源：

JOURNAL OF NEURAL TRANSMISSION | 2001年 / 108卷 / 02期

关键词：

amyloid beta-peptide; nerve growth factor; choline acetyltransferase; Alzheimer's disease; enzyme immunoassay; HPLC-ECD method; rats;

D O I：

10.1007/s007020170090

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Amyloid beta -peptide (A beta) is the major constituent of the senile plaques in the brains of patients with Alzheimer's disease. We have demonstrated previously that memory impairment, dysfunction of the cholinergic and dopaminergic neuronal system and morphological degeneration are produced after the continuous infusion of A beta into the cerebral ventricle in 8-week-old rat. In the present study, we investigated the toxicity of A beta in infant (10 days old), adult (8 weeks old) and aged (20 months old) rats in relation to nerve growth factor (NGF) content in various regions of the brain. After a 2-week-infusion, choline acetyltransferase (ChAT) activity was significantly decreased in the hippocampus of adult, but not infant or aged rats. NGF levels in the hippocampus were increased only in adult rats. These results suggest that A beta is toxic only in the matured adult brain, and that the mechanism of toxicity is related to NGF synthesis.

引用

页码：221 / 230

页数：10

共 39 条

[1] Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease [J].