Cell-free nucleic acids as biomarkers in cancer patients

被引：2246

作者：

Schwarzenbach, Heidi ^{[1
]}

Hoon, Dave S. B. ^{[2
]}

Pantel, Klaus ^{[1
]}

机构：

[1] Univ Med Ctr Hamburg Eppendorf, Ctr Med Expt, Inst Tumour Biol, D-20246 Hamburg, Germany

[2] John Wayne Canc Inst, Dept Mol Oncol, Santa Monica, CA 90404 USA

来源：

NATURE REVIEWS CANCER | 2011年 / 11卷 / 06期

基金：

美国国家卫生研究院;

关键词：

BARR-VIRUS DNA; CIRCULATING TUMOR-CELLS; CPG ISLAND HYPERMETHYLATION; BLOOD-BASED MARKERS; FREE SERUM DNA; PLASMA DNA; COLORECTAL-CANCER; BREAST-CANCER; QUANTITATIVE-ANALYSIS; PROSTATE-CANCER;

D O I：

10.1038/nrc3066

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

DNA, mRNA and microRNA are released and circulate in the blood of cancer patients. Changes in the levels of circulating nucleic acids have been associated with tumour burden and malignant progression. In the past decade a wealth of information indicating the potential use of circulating nucleic acids for cancer screening, prognosis and monitoring of the efficacy of anticancer therapies has emerged. In this Review, we discuss these findings with a specific focus on the clinical utility of cell-free nucleic acids as blood biomarkers.

引用

页码：426 / 437

页数：12

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