Vicious circles: a mechanism for yeast aging

被引：19

作者：

Defossez, PA ^{[1
]}

Park, PU ^{[1
]}

Guarente, L ^{[1
]}

机构：

[1] MIT, Dept Biol, Cambridge, MA USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 1998年 / 1卷 / 06期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1016/S1369-5274(98)80119-7

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The past year has confirmed the great potential of the yeast Saccharomyces cerevisiae as a model to study aging. Groundbreaking papers have revealed similarities between aging in yeast and in mammals, and have identified genetic instability of the ribosomal DNA array as the first known cause of aging in yeast cells.

引用

收藏

页码：707 / 711

页数：5

相关论文

共 46 条

[1] Perinuclear localization of chromatin facilitates transcriptional silencing [J].

Andrulis, ED ;

Neiman, AM ;

Zappulla, DC ;

Sternglanz, R .

NATURE, 1998, 394 (6693) :592-595

[2] The yeast silent information regulator Sir4p anchors and partitions plasmids [J].

Ansari, A ;

Gartenberg, MR .

MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (12) :7061-7068

[3] Changes of telomere length cause reciprocal changes in the lifespan of mother cells in Saccharomyces cerevisiae [J].

Austriaco, NR ;

Guarente, LP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (18) :9768-9772

[4] Extension of life-span by introduction of telomerase into normal human cells [J].

Bodnar, AG ;

Ouellette, M ;

Frolkis, M ;

Holt, SE ;

Chiu, CP ;

Morin, GB ;

Harley, CB ;

Shay, JW ;

Lichtsteiner, S ;

Wright, WE .

SCIENCE, 1998, 279 (5349) :349-352

[5] Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing [J].

Boulton, SJ ;

Jackson, SP .

EMBO JOURNAL, 1998, 17 (06) :1819-1828

[6] Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast [J].

Bryk, M ;

Banerjee, M ;

Murphy, M ;

Knudsen, KE ;

Garfinkel, DJ ;

Curcio, MJ .

GENES & DEVELOPMENT, 1997, 11 (02) :255-269

[7]

CONRADWEBB H, 1995, MOL CELL BIOL, V15, P2420

[8] TELOMERE LENGTH CONSTANCY DURING AGING OF SACCHAROMYCES-CEREVISIAE [J].

DMELLO, NP ;

JAZWINSKI, SM .

JOURNAL OF BACTERIOLOGY, 1991, 173 (21) :6709-6713

[9] EVIDENCE FOR THE INVOLVEMENT OF A CYTOPLASMIC FACTOR IN THE AGING OF THE YEAST SACCHAROMYCES-CEREVISIAE [J].

EGILMEZ, NK ;

JAZWINSKI, SM .

JOURNAL OF BACTERIOLOGY, 1989, 171 (01) :37-42

[10] Direct evidence for SIR2 modulation of chromatin structure in yeast rDNA [J].

Fritze, CE ;

Verschueren, K ;

Strich, R ;

Esposito, RE .

EMBO JOURNAL, 1997, 16 (21) :6495-6509

← 1 2 3 4 5 →