Vicious circles: a mechanism for yeast aging

被引:19
作者
Defossez, PA [1 ]
Park, PU [1 ]
Guarente, L [1 ]
机构
[1] MIT, Dept Biol, Cambridge, MA USA
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
D O I
10.1016/S1369-5274(98)80119-7
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The past year has confirmed the great potential of the yeast Saccharomyces cerevisiae as a model to study aging. Groundbreaking papers have revealed similarities between aging in yeast and in mammals, and have identified genetic instability of the ribosomal DNA array as the first known cause of aging in yeast cells.
引用
收藏
页码:707 / 711
页数:5
相关论文
共 46 条
[21]   MUTATION IN THE SILENCING GENE SIR4 CAN DELAY AGING IN SACCHAROMYCES-CEREVISIAE [J].
KENNEDY, BK ;
AUSTRIACO, NR ;
ZHANG, JS ;
GUARENTE, L .
CELL, 1995, 80 (03) :485-496
[22]   STABILITY OF RECOMBINANT PLASMIDS CONTAINING THE ARS SEQUENCE OF YEAST EXTRACHROMOSOMAL RDNA IN SEVERAL STRAINS OF SACCHAROMYCES-CEREVISIAE [J].
LARIONOV, V ;
KOUPRINA, N ;
KARPOVA, T .
GENE, 1984, 28 (02) :229-235
[23]   3 MU-M DNA - AN EXTRACHROMOSOMAL RIBOSOMAL DNA IN THE YEAST SACCHAROMYCES-CEREVISIAE [J].
LARIONOV, VL ;
GRISHIN, AV ;
SMIRNOV, MN .
GENE, 1980, 12 (1-2) :41-49
[24]   SILENCERS, SILENCING, AND HERITABLE TRANSCRIPTIONAL STATES [J].
LAURENSON, P ;
RINE, J .
MICROBIOLOGICAL REVIEWS, 1992, 56 (04) :543-560
[25]  
LIN YH, 1991, GENETICS, V127, P31
[26]   YEAST TELOMERE REPEAT SEQUENCE (TRS) IMPROVES CIRCULAR PLASMID SEGREGATION, AND TRS PLASMID SEGREGATION INVOLVES THE RAP1 GENE-PRODUCT [J].
LONGTINE, MS ;
ENOMOTO, S ;
FINSTAD, SL ;
BERMAN, J .
MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (05) :1997-2009
[27]   LIFE SPAN OF INDIVIDUAL YEAST CELLS [J].
MORTIMER, RK ;
JOHNSTON, JR .
NATURE, 1959, 183 (4677) :1751-1752
[28]   CALENDAR LIFE-SPAN VERSUS BUDDING LIFE-SPAN OF SACCHAROMYCES-CEREVISIAE [J].
MULLER, I ;
ZIMMERMANN, M ;
BECKER, D ;
FLOMER, M .
MECHANISMS OF AGEING AND DEVELOPMENT, 1980, 12 (01) :47-52
[29]   PARENTAL AGE AND THE LIFE-SPAN OF ZYGOTES OF SACCHAROMYCES-CEREVISIAE [J].
MULLER, I .
ANTONIE VAN LEEUWENHOEK JOURNAL OF MICROBIOLOGY, 1985, 51 (01) :1-10
[30]   PEDIGREE ANALYSIS OF PLASMID SEGREGATION IN YEAST [J].
MURRAY, AW ;
SZOSTAK, JW .
CELL, 1983, 34 (03) :961-970