Signaling pathways in apoptosis as potential targets-for cancer therapy

被引：62

作者：

Huang, P ^{[1
]}

Oliff, A ^{[1
]}

机构：

[1] Dupont Merck Pharmaceut Co, Glenolden, PA 19036 USA

来源：

TRENDS IN CELL BIOLOGY | 2001年 / 11卷 / 08期

关键词：

D O I：

10.1016/S0962-8924(01)02063-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Genetic instability contributes to the origin of cancer as well as to the ability of cancer cells to become resistant to various therapies. Because of this, cytotoxic rather than cytostatic therapies might be most effective against this disease. Many oncogenes and tumor suppressors mediate their effects by interfering with or inducing apoptotic signaling. Thus, apoptotic pathways might be significantly altered in cancer cells relative to untransformed cells, and these differences might present a therapeutic window that can be exploited for development of cancer drugs.

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页码：343 / +

页数：4

相关论文

共 62 条

[51] Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN [J].

Stambolic, V ;

Suzuki, A ;

de la Pompa, JL ;

Brothers, GM ;

Mirtsos, C ;

Sasaki, T ;

Ruland, J ;

Penninger, JM ;

Siderovski, DP ;

Mak, TW .

CELL, 1998, 95 (01) :29-39

[52] Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53 [J].

Stoll, R ;

Renner, C ;

Hansen, S ;

Palme, S ;

Klein, C ;

Belling, A ;

Zeslawski, W ;

Kamionka, M ;

Rehm, T ;

Mühlhahn, P ;

Schumacher, R ;

Hesse, F ;

Kaluza, B ;

Voelter, W ;

Engh, RA ;

Holak, TA .

BIOCHEMISTRY, 2001, 40 (02) :336-344

[53] Survivin initiates cell cycle entry by the competitive interaction with Cdk4/p16INK4a and Cdk2/Cyclin E complex activation [J].

Suzuki, A ;

Hayashida, M ;

Ito, T ;

Kawano, H ;

Nakano, T ;

Miura, M ;

Akahane, K ;

Shiraki, K .

ONCOGENE, 2000, 19 (29) :3225-3234

[54] Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3 [J].

Tzung, SP ;

Kim, KM ;

Basañez, G ;

Giedt, CD ;

Simon, J ;

Zimmerberg, J ;

Zhang, KYJ ;

Hockenbery, DM .

NATURE CELL BIOLOGY, 2001, 3 (02) :183-191

[55] Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival [J].

Vander Heiden, MG ;

Chandel, NS ;

Li, XX ;

Schumacker, PT ;

Colombini, M ;

Thompson, CB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (09) :4666-4671

[56]

Vander Heiden MG, 1999, MOL CELL, V3, P159

[57] Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins [J].

Verhagen, AM ;

Ekert, PG ;

Pakusch, M ;

Silke, J ;

Connolly, LM ;

Reid, GE ;

Moritz, RL ;

Simpson, RJ ;

Vaux, DL .

CELL, 2000, 102 (01) :43-53

[58] p53: Death star [J].

Vousden, KH .

CELL, 2000, 103 (05) :691-694

[59] Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells [J].

Wang, JL ;

Liu, DX ;

Zhang, ZJ ;

Shan, SM ;

Han, XB ;

Srinivasula, SM ;

Croce, CM ;

Alnemri, ES ;

Huang, ZW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (13) :7124-7129

[60] Structural basis of IAP recognition by Smac/DIABLO [J].

Wu, G ;

Chai, JJ ;

Suber, TL ;

Wu, JW ;

Du, CY ;

Wang, XD ;

Shi, YG .

NATURE, 2000, 408 (6815) :1008-1012

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