Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine-endothelial cell interactions

被引：367

作者：

Kawanami, D

Maemura, K

Takeda, N

Harada, T

Nojiri, T

Imai, Y

Manabe, I

Utsunomiya, K

Nagai, R

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo, Japan

[2] Jikei Univ, Sch Med, Dept Internal Med, Div Diabet & Endocrinol,Minato Ku, Tokyo, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 314卷 / 02期

关键词：

endothelium; inflammation; atherosclerosis;

D O I：

10.1016/j.bbrc.2003.12.104

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Resistin is an adipocytokine which plays a role in the development of insulin resistance. In this study, we investigated the direct effect of resistin on vascular endothelial cells. Resistin induced the expression of adhesion molecules such as VCAM-1 and ICAM-1, and long pentraxin 3, a marker of inflammation. The induction of VCAM-1 by resistin was inhibited partially by pitavastatin. Moreover, the induction of VCAM-1 and ICAM-1 by resistin was inhibited by adiponectin, an adipocytokine that improves insulin resistance. Taken together, these results suggest that the balance in the concentrations of adipocytokines such as resistin and adiponectin determines the inflammation status of vasculature, and in turn the progress of atherosclerosis. (C) 2003 Elsevier Inc. All rights reserved.

引用

收藏

页码：415 / 419

页数：5

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