Bex1, a gene with increased expression in parthenogenetic embryos, is a member of a novel gene family on the mouse X chromosome

被引:55
作者
Brown, AL [1 ]
Kay, GF [1 ]
机构
[1] Queensland Inst Med Res & Univ Queensland, QCF Transgen Lab, Joint Expt Oncol Program, PO Royal Brisbane Hosp, Brisbane, Qld 4029, Australia
关键词
D O I
10.1093/hmg/8.4.611
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Parthenogenetic and normal blastocysts were compared using differential display analysis as a means to identify new imprinted genes, A single gene was identified with increased expression in parthenogenetic blastocysts, suggesting it might be an imprinted gene expressed from the maternally inherited allele, The gene, named Bex1 (brain expressed X-linked gene), maps near Pip on the mouse X chromosome and to Xq22 in humans. Database homology searches revealed two additional uncharacterized cDNAs similar to Bex1 that were named Bex2 and Bex3. Allele-specific expression analysis of Bex1 using Fl blastocysts indicated an excess of transcript expressed from the maternally inherited allele compared with the paternally inherited allele, This excess level of transcript derived from the maternally inherited allele may be due to imprinted X inactivation of the paternally inherited allele in the extraembryonic lineages of female embryos rather than a result of genomic imprinting.
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收藏
页码:611 / 619
页数:9
相关论文
共 38 条
[1]   PAK3 mutation in nonsyndromic X-linked mental retardation [J].
Allen, KM ;
Gleeson, JG ;
Bagrodia, S ;
Partington, MW ;
MacMillan, JC ;
Cerione, RA ;
Mulley, JC ;
Walsh, CA .
NATURE GENETICS, 1998, 20 (01) :25-30
[2]   X-CHROMOSOME INACTIVATION MAY EXPLAIN THE DIFFERENCE IN VIABILITY OF XO HUMANS AND MICE [J].
ASHWORTH, A ;
RASTAN, S ;
LOVELLBADGE, R ;
KAY, G .
NATURE, 1991, 351 (6325) :406-408
[3]  
Beamer WG, 1998, CANCER RES, V58, P3694
[4]   TOWARDS HIGH-RESOLUTION MAPS OF THE MOUSE AND HUMAN GENOMES - A FACILITY FOR ORDERING MARKERS TO 0.1 CM RESOLUTION [J].
BREEN, M ;
DEAKIN, L ;
MACDONALD, B ;
MILLER, S ;
SIBSON, R ;
TARTTELIN, E ;
AVNER, P ;
BOURGADE, F ;
GUENET, JL ;
MONTAGUTELLI, X ;
POIRIER, C ;
SIMON, D ;
TAILOR, D ;
BISHOP, M ;
KELLY, M ;
RYSAVY, F ;
RASTAN, S ;
NORRIS, D ;
SHEPHERD, D ;
ABBOTT, C ;
PILZ, A ;
HODGE, S ;
JACKSON, I ;
BOYD, Y ;
BLAIR, H ;
MASLEN, G ;
TODD, JA ;
REED, PW ;
STOYE, J ;
ASHWORTH, A ;
MCCARTHY, L ;
COX, R ;
SCHALKWYK, L ;
LEHRACH, H ;
KLOSE, J ;
GANGADHARAN, U ;
BROWN, S .
HUMAN MOLECULAR GENETICS, 1994, 3 (04) :621-627
[5]   X inactivation analysis and DNA methylation studies of the ubiquitin activating enzyme E1 and PCTAIRE-1 genes in human and mouse [J].
Carrel, L ;
Clemson, CM ;
Dunn, JM ;
Miller, AP ;
Hunt, PA ;
Lawrence, JB ;
Willard, HF .
HUMAN MOLECULAR GENETICS, 1996, 5 (03) :391-401
[6]  
Carrel L, 1996, AM J MED GENET, V64, P27, DOI 10.1002/(SICI)1096-8628(19960712)64:1<27::AID-AJMG3>3.0.CO
[7]  
2-O
[8]   EVIDENCE OF NONRANDOM X-CHROMOSOME ACTIVITY IN MOUSE [J].
CATTANACH, BM ;
WILLIAMS, CE .
GENETICS RESEARCH, 1972, 19 (03) :229-+
[9]   A low-copy repeat in Xq26 represents a novel putatively prenylated protein gene (CXX1) and its pseudogenes (DXS9914, DXS9915, and DXS9916) [J].
Frattini, A ;
Faranda, S ;
Zucchi, I ;
Vezzoni, P .
GENOMICS, 1997, 46 (01) :167-169
[10]   ALL RAS PROTEINS ARE POLYISOPRENYLATED BUT ONLY SOME ARE PALMITOYLATED [J].
HANCOCK, JF ;
MAGEE, AI ;
CHILDS, JE ;
MARSHALL, CJ .
CELL, 1989, 57 (07) :1167-1177