TOWARDS HIGH-RESOLUTION MAPS OF THE MOUSE AND HUMAN GENOMES - A FACILITY FOR ORDERING MARKERS TO 0.1 CM RESOLUTION

被引：165

作者：

BREEN, M

DEAKIN, L

MACDONALD, B

MILLER, S

SIBSON, R

TARTTELIN, E

AVNER, P

BOURGADE, F

GUENET, JL

MONTAGUTELLI, X

POIRIER, C

SIMON, D

TAILOR, D

BISHOP, M

KELLY, M

RYSAVY, F

RASTAN, S

NORRIS, D

SHEPHERD, D

ABBOTT, C

PILZ, A

HODGE, S

JACKSON, I

BOYD, Y

BLAIR, H

MASLEN, G

TODD, JA

REED, PW

STOYE, J

ASHWORTH, A

MCCARTHY, L

COX, R

SCHALKWYK, L

LEHRACH, H

KLOSE, J

GANGADHARAN, U

BROWN, S

机构：

[1] ST MARYS HOSP,SCH MED,DEPT BIOCHEM & MOLEC GENET,LONDON W2 1PG,ENGLAND

[2] MRC,CLIN RES CTR,CTR HUMAN GENOME MAPPING PROJECT RESOURCE CTR,HARROW HA1 3UJ,MIDDX,ENGLAND

[3] INST PASTEUR,PARIS,FRANCE

[4] MRC,CLIN RES CTR,COMP SERV,HARROW HA1 3UJ,MIDDX,ENGLAND

[5] MRC,CLIN RES CTR,COMPARAT BIOL SECT,HARROW HA1 3UJ,MIDDX,ENGLAND

[6] UNIV LONDON,GALTON LAB,LONDON,ENGLAND

[7] MRC,HUMAN GENET UNIT,EDINBURGH,SCOTLAND

[8] MRC,RADIOBIOL UNIT,DIDCOT,OXON,ENGLAND

[9] UNIV OXFORD,JOHN RADCLIFFE HOSP,NUFFIELD DEPT SURG,OXFORD OX3 9DU,ENGLAND

[10] NATL INST MED RES,MRC,LONDON NW7 1AA,ENGLAND

[11] INST CANC RES,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLAND

[12] FREE UNIV BERLIN,INST HUMAN GENET,D-14195 BERLIN,GERMANY

[13] IMPERIAL CANC RES FUND,LONDON WC2A 3PX,ENGLAND

来源：

HUMAN MOLECULAR GENETICS | 1994年 / 3卷 / 04期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1093/hmg/3.4.621

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

982 progeny produced by a mouse interspecific backcross between C57BL/6 and Mus spretus have been scored for at least 3 markers on each chromosome, completing an anchor map of 78 loci across the mouse genome. The anchor mapping identifies all the available recombinants in each interanchor interval allowing access to panels of mice that can be used for the high resolution mapping of any chromosome region. The large number of progeny recovered and scored from the interspecific backcross allows us to resolve genetically markers that lie on average 200 kb apart on mouse chromosomes and within the cloning capacity of currently available YAC libraries. EUCIB provides the first genetic mapping resource specifically designed for the high resolution mapping of all regions of the mouse genome and will underpin the global physical mapping of the mouse genome. In addition, with the use of conserved sequences the facility is applicable to the high resolution comparative mapping of the mouse and human genomes. A new database has been implemented to support the computation of high resolution and ordered genetic maps.

引用

页码：621 / 627

页数：7

共 35 条

[1] RELOCALIZATION OF ACTSK-1 TO MOUSE CHROMOSOME-8, A NEW REGION OF HOMOLOGY WITH HUMAN CHROMOSOME-1
ALONSO, S
MONTAGUTELLI, X
SIMONCHAZOTTES, D
GUENET, JL
BUCKINGHAM, M
[J]. MAMMALIAN GENOME, 1993, 4 (01) : 15 - 20
[2] GENETIC-ANALYSIS OF THE MOUSE USING INTERSPECIFIC CROSSES
AVNER, P
AMAR, L
DANDOLO, L
GUENET, JL
[J]. TRENDS IN GENETICS, 1988, 4 (01) : 18 - 23
[3] CONSTRUCTION OF A DETAILED MOLECULAR MAP OF THE MOUSE X-CHROMOSOME BY MICROCLONING AND INTERSPECIFIC CROSSES
BROCKDORFF, N
FISHER, EMC
CAVANNA, JS
LYON, MF
BROWN, SDM
[J]. EMBO JOURNAL, 1987, 6 (11) : 3291 - 3297
[4] THE MOUSE GENOME PROJECT AND HUMAN-GENETICS - A REPORT FROM THE 5TH INTERNATIONAL MOUSE GENOME MAPPING WORKSHOP, LUNTEREN, HOLLAND
BROWN, SDM
[J]. GENOMICS, 1992, 13 (02) : 490 - 492
[5] A MOLECULAR GENETIC-LINKAGE MAP OF MOUSE CHROMOSOME-4 INCLUDING THE LOCALIZATION OF SEVERAL PROTO-ONCOGENES
CECI, JD
SIRACUSA, LD
JENKINS, NA
COPELAND, NG
[J]. GENOMICS, 1989, 5 (04) : 699 - 709
[6] CONSTRUCTION OF A MOUSE YEAST ARTIFICIAL CHROMOSOME LIBRARY IN A RECOMBINATION-DEFICIENT STRAIN OF YEAST
CHARTIER, FL
KEER, JT
SUTCLIFFE, MJ
HENRIQUES, DA
MILEHAM, P
BROWN, SDM
[J]. NATURE GENETICS, 1992, 1 (02) : 132 - 136
[7] A GENETIC-LINKAGE MAP OF THE MOUSE - CURRENT APPLICATIONS AND FUTURE-PROSPECTS
COPELAND, NG
JENKINS, NA
GILBERT, DJ
EPPIG, JT
MALTAIS, LJ
MILLER, JC
DIETRICH, WF
WEAVER, A
LINCOLN, SE
STEEN, RG
STEIN, LD
NADEAU, JH
LANDER, ES
[J]. SCIENCE, 1993, 262 (5130) : 57 - 66
[8] THE GENERATION OF A LIBRARY OF PCR-ANALYZED MICROSATELLITE VARIANTS FOR GENETIC-MAPPING OF THE MOUSE GENOME
CORNALL, RJ
AITMAN, TJ
HEARNE, CM
TODD, JA
[J]. GENOMICS, 1991, 10 (04) : 874 - 881
[9] INTERSPERSED REPETITIVE ELEMENT POLYMERASE CHAIN-REACTION PRODUCT MAPPING USING A MOUSE INTERSPECIFIC BACKCROSS
COX, RD
COPELAND, NG
JENKINS, NA
LEHRACH, H
[J]. GENOMICS, 1991, 10 (02) : 375 - 384
[10] DIETRICH W, 1992, GENETICS, V131, P423

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