Chemical modification of chitosan 8: preparation of chitosan-dendrimer hybrids via short spacer

被引：29

作者：

Sashiwa, H

Shigemasa, Y

Roy, R

机构：

[1] Univ Ottawa, Dept Chem, Ottawa, ON K1N 6N5, Canada

[2] Tottori Univ, Fac Engn, Tottori 6808552, Japan

来源：

CARBOHYDRATE POLYMERS | 2002年 / 47卷 / 02期

关键词：

chitosan; dendrimer; polyamide amine; aldehyde; sialic acid; short spacer;

D O I：

10.1016/S0144-8617(01)00166-7

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Polyamidoamine (PAMAM) dendrimers of various generations (G = 0.5-5) were prepared from commercial aminoacetaldehyde diethyl acetal. After transforming acetal to aldehyde, chitosan-dendrimer hybrids were prepared by reductive N-alkylation. The reactivity of dendrimer to primary amino group of chitosan was decreased at G = 3.5 or above MW > 6305. Chitosan-sialodendrimer hybrid (G 3) was also prepared under the same conditions. (C) 2002 Elsevier Science Ltd. All rights reserved.

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收藏

页码：191 / 199

页数：9

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