Apolipoprotein E4 and Brain White Matter Integrity in Alzheimer's Disease: Tract-Based Spatial Statistics Study under 3-Tesla MRI

被引：14

作者：

Bagepally, Bhavani Shankara ^{[1
]}

Halahalli, Harsha N. ^{[1
]}

John, John P. ^{[1
]}

Kota, Lakshminarayan ^{[1
]}

Purushottam, Meera ^{[1
]}

Mukherjee, Odity ^{[2
]}

Sivakumar, Palanimuthu Thangaraju ^{[1
]}

Bharath, Srikala ^{[1
]}

Jain, Sanjeev ^{[1
]}

Varghese, Mathew ^{[1
]}

机构：

[1] Natl Inst Mental Hlth & Neurosci, Bangalore 560029, Karnataka, India

[2] Natl Ctr Biol Sci, Bangalore, Karnataka, India

来源：

NEURODEGENERATIVE DISEASES | 2012年 / 10卷 / 1-4期

关键词：

Brain white matter integrity; Alzheimer's disease; Apolipoprotein E4 polymorphism; MILD COGNITIVE IMPAIRMENT; APOE EPSILON-4 ALLELE; APOE-EPSILON-4; RISK;

D O I：

10.1159/000334761

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Introduction: Apolipoprotein E4 (ApoE epsilon 4) polymorphism is a known genetic risk factor for Alzheimer's disease (AD). Objectives: To evaluate the role of ApoE epsilon 4 on white matter structural integrity in AD. Methods: Subjects were 32 patients with probable AD (ApoE epsilon 4-positive: n = 15) and 18 matched controls (ApoE epsilon 4-positive: n = 6). All subjects were right-handed, evaluated using standard scales and genotyped at the ApoE locus. Diffusion tensor imaging was performed with a 3-tesla MRI scanner and analyzed using the tract-based spatial statistics method. Results: AD patients had significantly lower fractional anisotropy (FA) in bilateral temporoparietal, limbic and parahippocampal regions in comparison to healthy comparison subjects. ApoE epsilon 4 carriers among both AD and healthy comparison subjects showed lower FA in limbic and medial temporal regions. Conclusions: There is a modest association between ApoE epsilon 4 carrier status and reduction in white matter tract integrity at medial temporal and limbic regions in both healthy and AD subjects. Copyright (C) 2012 S. Karger AG, Basel

引用

页码：145 / 148

页数：4

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