Determination of losartan and its degradates in COZAAR® tablets by reversed-phase high-performance thin-layer chromatography

被引：77

作者：

McCarthy, KE ^{[1
]}

Wang, QX ^{[1
]}

Tsai, EW ^{[1
]}

Gilbert, RE ^{[1
]}

Ip, DP ^{[1
]}

Brooks, MA ^{[1
]}

机构：

[1] Merck Res Labs, Pharmaceut Res & Dev, W Point, PA 19486 USA

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1998年 / 17卷 / 4-5期

关键词：

HPTLC; losartan potassium; quantitation; stability;

D O I：

10.1016/S0731-7085(97)00251-3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Losartan potassium is an angiotensin II receptor blocker. It has been formulated and marketed as a tablet dosage form (COZAAR(R). A reversed-phase high-performance thin-layer chromatography method has been developed for the determination of losartan and its low level dimeric degradates (E and Fl. The method has been validated and shown to be sensitive, efficient. and reliable, and can be used as an excellent alternative to the HPLC stability testing of losartan potassium in COZAAR(R) tablets. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：671 / 677

页数：7

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