Powerful chiral phase-transfer catalysts for the asymmetric synthesis of α-alkyl- and α,α,-dialkyl-α-amino acids

被引：192

作者：

Kitamra, M ^{[1
]}

Shirakawa, S ^{[1
]}

Maruoka, K ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Sci, Dept Chem, Sakyo Ku, Kyoto 6068502, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 10期

关键词：

alkylation; amino acids; enantioselectivity; glycine; phase-transfer catalysis;

D O I：

10.1002/anie.200462257

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The catalytic performance of the chiral phase-transfer catalyst 1 (0.1-0.01 mol%) in the asymmetric alkylation of protected glycine and alanine derivatives exceeds that of existing catalysts. The reaction is used in the enantioselective synthesis of structurally diverse natural and non-natural α-alkyl and α,α-dialkyl-α-amino acids. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1549 / 1551

页数：3

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