Frequency dependence of cytochrome oxidase activity in magnetic fields

被引：27

作者：

Blank, M ^{[1
]}

Soo, L ^{[1
]}

机构：

[1] Columbia Univ, Dept Physiol & Cellular Biophys, New York, NY 10032 USA

来源：

BIOELECTROCHEMISTRY AND BIOENERGETICS | 1998年 / 46卷 / 01期

关键词：

magnetic fields; electromagnetic fields; cytochrome oxidase; redox reaction kinetics; electron transport; frequency dependence;

D O I：

10.1016/S0302-4598(98)00126-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Magnetic fields increase the activity of cytochrome oxidase, apparently accelerating electron movements during the oxidation of cytochrome C. The increase due to magnetic fields varies inversely with the basal enzyme reaction rate. In this paper, we show that increases in the reaction rate constant in magnetic fields vary with frequency, in the range 10-2500 Hz, with a maximum in the range 500-1000 Hz. The frequency dependence of the cytochrome oxidase is similar to earlier described effects of electric and magnetic fields on the membrane enzymes, Na,K-ATPase and F0F1-ATPase, where optimal frequencies are in ranges of the turnover numbers of the enzyme reactions. (C) 1998 Elsevier Science S.A. All rights reserved.

引用

页码：139 / 143

页数：5

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