Predictors of lymphoma development in primary Sjogren's syndrome

被引：106

作者：

Sutcliffe, N

Inanc, M

Speight, P

Isenberg, D

机构：

[1] UCL, Dept Med, Bloomsbury Rheumatol Unit, Ctr Rheumatol, London WC1E 6BT, England

[2] Eastman Dent Inst, Dept Oral Pathol, London, England

来源：

SEMINARS IN ARTHRITIS AND RHEUMATISM | 1998年 / 28卷 / 02期

关键词：

Sjogren's syndrome; lymphoma; primary Sjogren's syndrome; MALT lymphoma;

D O I：

10.1016/S0049-0172(98)80040-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To determine the clinical and laboratory predictors of lymphoma development in primary Sjogren's syndrome (pSS). Methods: Seventy-two patients with pSS were studied. Demographic data, clinical features, serum gamma-globulin levels, autoantibodies, and HLA status were reviewed, For statistical analysis, Mann-Whitney U-test, Fisher's exact test, logistic regression analysis, Kaplan-Meier method, and log-rank tests were applied, Results:Five patients developed a distinct non-Hodgkin's lymphoma of mucosa-associated lymphoid tissue (MALT), A history of swollen salivary glands, lymphadenopathy, and leg ulcers predicted lymphoma development. Conclusion: Patients with pSS are at increased risk of lymphoma development and those who have the above risk factors must be carefully observed. Copyright (C) 1998 by W.B. Saunders Company.

引用

页码：80 / 87

页数：8

共 29 条

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