From disulfide- to thioether-linked glycoproteins

被引：118

作者：

Bernardes, Goncalo J. L. ^{[1
]}

Grayson, Elizabeth J. ^{[1
,2
]}

Thompson, Sam ^{[1
]}

Chalker, Justin M. ^{[1
]}

Errey, James C. ^{[1
]}

El Oualid, Farid ^{[1
]}

Claridge, Timothy D. W. ^{[1
]}

Davis, Benjamin G. ^{[1
]}

机构：

[1] Univ Oxford, Chem Res Lab, Dept Chem, Oxford OX1 3TA, England

[2] Univ Durham, Dept Chem, Durham DH1 3LE, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 12期

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

disulfides; glycoproteins; glycosylation; protein modifications; thioethers;

D O I：

10.1002/anie.200704381

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Presented) Strengthening the bond: The introduction of a thiol tag in combination with chemoselective ligation to form a disulfide-linked bioconjugate is a selective and useful method for site-selective protein glycosylation. The phosphine-mediated desulfurization of such glycoconjugates to their reductant-resistant thioether-linked counterparts completes a convergent, site-selective synthesis of thioether-linked glycoproteins (see scheme). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2244 / 2247

页数：4

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