Stereoselective synthesis of alkenylated malonic diamide using masked acyl cyanide

被引：21

作者：

Nemoto, H

Ibaragi, T

Bando, M

Kido, M

Shibuya, M

机构：

[1] Univ Tokushima, Fac Pharmaceut Sci, Tokushima 7708505, Japan

[2] Otsuka Pharmaceut Co Ltd, Tokushima Inst New Drug Res 2, Tokushima 7700129, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 07期

关键词：

cyanides; epimerization; acyl anion; palladium and compounds;

D O I：

10.1016/S0040-4039(98)02601-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly stereoselective synthesis of an alkenylated malonic diamide starting from a gamma,delta-epoxy-alpha,beta-unsaturated carboxamide was accomplished using the masked acyl cyanide (MAC: the protected hydroxymalonitrile) via palladium-catalyzed regio- and stereoselective carbon-carbon bond formation. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：1319 / 1322

页数：4

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