Biodegradable dual-crosslinked adhesive glue for fixation and promotion of osteogenesis

被引：53

作者：

Hou, Fushan ^{[1
,2
]}

Jiang, Wei ^{[3
]}

Zhang, Yin ^{[4
]}

Tang, Jincheng ^{[1
]}

Li, Dong ^{[2
]}

Zhao, Bin ^{[2
]}

Wang, Lei ^{[4
]}

Gu, Yong ^{[1
]}

Cui, Wenguo ^{[4
]}

Chen, Liang ^{[1
]}

机构：

[1] First Affiliated Hosp Soochow Univ, Dept Orthopaed Surg, 899 Pinghai Rd, Suzhou 215031, Jiangsu, Peoples R China

[2] Second Hosp Shanxi Med Univ, Dept Orthopaed, 382 Wuyi Rd, Taiyuan 030001, Shanxi, Peoples R China

[3] Fourth Affiliated Hosp Anhui Med Univ, Dept Orthopaed, 100 Huaihai Rd,Xinzhan Dist, Hefei 230012, Anhui, Peoples R China

[4] Shanghai Jiao Tong Univ Sch Med, Ruijin Hosp, Shanghai Inst Traumatol & Orthopaed, Dept Orthopaed,Shanghai Key Lab Prevent & Treatme, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China

来源：

CHEMICAL ENGINEERING JOURNAL | 2022年 / 427卷

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

Dual-crosslinking; Biodegradable; Osteogenesis; Adhesive glue; STERNAL CLOSURE; TOUGH HYDROGEL; BONE ADHESIVE; STRENGTH; DEXTRAN; HYDROXYAPATITE; PROTEIN; CEMENT;

D O I：

10.1016/j.cej.2021.132000

中图分类号：

X [环境科学、安全科学];

学科分类号：

083001 [环境科学];

摘要：

The effective fixation of fracture fragments is the foundation for the smooth healing process of fracture. Due to the presence of small fracture fragments, the comminuted fracture cannot be fixed under high mechanical strength leading to the bone nonunion and delayed healing. In this study, the primary crosslinked injectable bone glue was fabricated by the Schiff base reaction between low substitution degree methacrylate gelatin (GelMa) and Oxidized dextran (oDex) covalently crosslinked with Aminated mesoporous bioactive glass nanoparticles (AMBGN), then the second crosslinked bone glue was formed among small fracture fragments after the irradiation. By this method, the osteogenic dual-crosslinking biodegradable bone glue was synthesized with enhanced mechanical capability. This bone glue was biocompatible and biodegradable, in addition, after the second crosslinking, the mechanical strength was 2.1 times higher than that in primary cross-linking. Moreover, the dual-crosslinked bone glue also exhibited excellent adhesion ability on the isolated rat bone tissues. Additionally, the bone glue can increase the proliferation of bone marrow mesenchymal stem cells (BMSCs) and enhance the expression of Alkaline phosphatase (ALP) and the deposition of calcium nodules with the up-regulating expression of the osteogenic protein (Runx2) and adhesin (Vinculin) in vitro. Furthermore, the bone glue also presented enhanced osteogenesis in the rat calvarial critical-size defect models in vivo. Overall, this osteogenic dual-crosslinking biodegradable bone glue with high mechanical strength provided a new approach in treating the comminuted fracture fragments.

引用

页数：13

共 47 条

[11]

Deleterious tissue reaction to an alkylene bis(dilactoyl)-methacrylate bone adhesive in long-term follow up after screw augmentation in an ovine model [J].