Constructing minimal models for complex system dynamics

被引:61
作者
Barzel, Baruch [1 ]
Liu, Yang-Yu [2 ,3 ]
Barabasi, Albert-Laszlo [3 ,4 ,5 ,6 ,7 ,8 ,9 ]
机构
[1] Bar Ilan Univ, Dept Math, IL-52900 Ramat Gan, Israel
[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Channing Div Network Med, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Dana Farber Canc Inst, Ctr Canc Syst Biol, Boston, MA 02115 USA
[4] Northeastern Univ, Ctr Complex Network Res, Boston, MA 02115 USA
[5] Northeastern Univ, Dept Phys, Boston, MA 02115 USA
[6] Northeastern Univ, Dept Comp Sci, Boston, MA 02115 USA
[7] Northeastern Univ, Dept Biol, Boston, MA 02115 USA
[8] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med, Boston, MA 02115 USA
[9] Cent European Univ, Ctr Network Sci, H-1052 Budapest, Hungary
关键词
PHYSICS;
D O I
10.1038/ncomms8186
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
One of the strengths of statistical physics is the ability to reduce macroscopic observations into microscopic models, offering a mechanistic description of a system's dynamics. This paradigm, rooted in Boltzmann's gas theory, has found applications from magnetic phenomena to subcellular processes and epidemic spreading. Yet, each of these advances were the result of decades of meticulous model building and validation, which are impossible to replicate in most complex biological, social or technological systems that lack accurate microscopic models. Here we develop a method to infer the microscopic dynamics of a complex system from observations of its response to external perturbations, allowing us to construct the most general class of nonlinear pairwise dynamics that are guaranteed to recover the observed behaviour. The result, which we test against both numerical and empirical data, is an effective dynamic model that can predict the system's behaviour and provide crucial insights into its inner workings.
引用
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页数:8
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