Synthesis of (-)-aphanorphine using aryl radical cyclization

被引：51

作者：

Tamura, O ^{[1
]}

Yanagimachi, T ^{[1
]}

Kobayashi, T ^{[1
]}

Ishibashi, H ^{[1
]}

机构：

[1] Kanazawa Univ, Fac Pharmaceut Sci, Kanazawa, Ishikawa 9200934, Japan

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 16期

关键词：

D O I：

10.1021/ol015818j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The synthesis of (-)-aphanorphine was achieved by using Bu3SnH-mecliated aryl radical cyclization of 1-benzyloxycarbonyl-2-(2-bromo-4-methoxyphenylmethyl)-2-methoxycarbonyl-4-(phenylthiomethylene)pyrrolidine, leading to exclusive formation of the 6-exo cyclization product.

引用

页码：2427 / 2429

页数：3

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