The effect of hypertonic saline dextran on whole blood coagulation

被引：11

作者：

Coats, TJ ^{[1
]}

Heron, M ^{[1
]}

机构：

[1] Univ London, Royal London Hosp, Barts & London Queen Marys Sch Med, Dept Accid & Emergency, London E1 1BB, England

来源：

RESUSCITATION | 2004年 / 60卷 / 01期

关键词：

fluid therapy; coagulation; hypertonic saline dextran;

D O I：

10.1016/j.resuscitation.2003.08.001

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Hypertonic saline dextran (RescueFlow) is being promoted for resuscitation from hypovolaemia following injury. We studied the in vitro effect on coagulation of serial dilutions of blood with this fluid. There was a mild procoagulant effect up to a dilution of 11% and an anticoagulant effect above this level, which rapidly increased so that coagulation was grossly deranged at a 15% dilution. Although the clinical significance of these findings is not yet known, it may suggest that for hypertonic saline dextran there is little to separate the top of the therapeutic window from the threshold of potentially serious adverse effects. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：101 / 104

页数：4

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