Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium

被引：98

作者：

Li, Xuri ^{[1
,2
]}

Tjwa, Marc ^{[1
]}

Van Hove, Inge ^{[1
]}

Enholm, Berndt ^{[3
]}

Neven, Elke ^{[1
]}

Paavonen, Karri ^{[3
]}

Jeltsch, Michael ^{[3
]}

Juan, Toni Diez ^{[1
]}

Sievers, Richard E. ^{[4
]}

Chorianopoulos, Emmanuel ^{[1
]}

Wada, Hiromichi ^{[1
]}

Vanwildemeersch, Maarten ^{[2
]}

Noel, Agnes ^{[5
]}

Foidart, Jean-Michel ^{[5
]}

Springer, Matthew L. ^{[4
,6
]}

von Degenfeld, Georges ^{[6
]}

Dewerchin, Mieke ^{[1
]}

Blau, Helen M. ^{[6
]}

Alitalo, Kari ^{[3
]}

Eriksson, Ulf ^{[2
]}

Carmeliet, Peter ^{[1
]}

Moons, Lieve ^{[1
]}

机构：

[1] Katholieke Univ Leuven VIB, VRC, B-3000 Louvain, Belgium

[2] Karolinska Inst, Ludwig Inst Canc Res, Stockholm, Sweden

[3] Univ Helsinki, Biomedicum Helsinki, Lab Mol Canc Biol, FIN-00014 Helsinki, Finland

[4] Univ Calif San Francisco, Div Cardiol, San Francisco, CA 94143 USA

[5] Univ Liege, Lab Biol Tumors & Dev, B-4000 Liege, Belgium

[6] Stanford Univ, Baxter Lab Genet Pharmacol, Stanford, CA 94305 USA

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2008年 / 28卷 / 09期

基金：

瑞典研究理事会;

关键词：

VEGF-B; angiogenesis; arteriogenesis; collateral growth; cardiac ischemia; limb ischemia;

D O I：

10.1161/ATVBAHA.107.158725

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective-The endogenous role of the VEGF family member vascular endothelial growth factor-B (VEGF-B) in pathological angiogenesis remains unclear. Methods and Results-We studied the role of VEGF-B in various models of pathological angiogenesis using mice lacking VEGF-B (VEGF-B-/-) or overexpressing VEGF-B-167. After occlusion of the left coronary artery, VEGF-B deficiency impaired vessel growth in the ischemic myocardium whereas, in wild-type mice, VEGF-B-167 overexpression enhanced revascularization of the infarct and ischemic border zone. By contrast, VEGF-B deficiency did not affect vessel growth in the wounded skin, hypoxic lung, ischemic retina, or ischemic limb. Moreover, VEGF-B-167 overexpression failed to enhance vascular growth in the skin or ischemic limb. Conclusion-VEGF-B appears to have a relatively restricted angiogenic activity in the ischemic heart. These insights might offer novel therapeutic opportunities.

引用

页码：1614 / 1620

页数：7

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