Aqueous phosphoester bond cleavage of dimethyl phosphate by Cp2MoCl2:: First reported case of hydrolytic cleavage on an unactivated phosphate diester by an organometallic complex

被引:42
作者
Kuo, LY [1 ]
Barnes, LA [1 ]
机构
[1] Lewis & Clark Coll, Dept Chem, Portland, OR 97219 USA
关键词
D O I
10.1021/ic970462m
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
The organometallic compound bis(eta(5)-cyclopentadienyl) molybdenum(IV) dichloride (Cp2MoCl2, Cp = beta(5)-C5H5) promotes the phosphotester bond cleavage of dimethyl phosphate with rate accelerations of 10(4) at pH 4.0. NMR spectral evidence suggests this phosphoester bond cleavage proceeds through a hydrolytic pathway where the aquated Cp2MoCl2 binds to the phosphate diester and then carries out an intramolecular attack with either a Cp2Mo-bound water or hydroxide. This is the first reported case of an organometallic complex that hydrolyzes an unactivated phosphate diester.
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页码:814 / 817
页数:4
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