NKT cells in tumor immunity: Opposing subsets define a new immunoregulatory axis

被引：97

作者：

Berzofsky, Jay A. ^{[1
]}

Terabe, Masaki ^{[1
]}

机构：

[1] NCI, Vaccine Branch, Bethesda, MD 20892 USA

来源：

JOURNAL OF IMMUNOLOGY | 2008年 / 180卷 / 06期

关键词：

D O I：

10.4049/jimmunol.180.6.3627

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

NKTcells are true Ag-specific T cells that also have innate properties and form a bridge between the innate and adaptive immune systems. Distinct NKT cell subsets play positive and negative regulatory roles and define a new immunoregulatory axis with broad implications for tumor immunity and other immunological and disease settings.

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收藏

页码：3627 / 3635

页数：9

相关论文

共 127 条

[1] CD4+ invariant T-cell-receptor plus natural killer T cells in bronchial asthma. [J].

Akbari, O ;

Faul, JL ;

Hoyte, EG ;

Berry, GJ ;

Wahlström, J ;

Kronenberg, M ;

DeKruyff, RH ;

Umetsu, DT .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (11) :1117-1129

[2] Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity [J].

Akbari, O ;

Stock, P ;

Meyer, E ;

Kronenberg, M ;

Sidobre, S ;

Nakayama, T ;

Taniguchi, M ;

Grusby, MJ ;

DeKruyff, RH ;

Umetsu, DT .

NATURE MEDICINE, 2003, 9 (05) :582-588

[3] Cross-regulation between type I and type IINKT cells in regulating tumor immunity: A new immunoregulatory axis [J].

Ambrosino, Elena ;

Terabe, Masaki ;

Halder, Ramesh C. ;

Peng, Judy ;

Takaku, Shun ;

Miyake, Sachiko ;

Yamamura, Takashi ;

Kumar, Vipin ;

Berzofsky, Jay A. .

JOURNAL OF IMMUNOLOGY, 2007, 179 (08) :5126-5136

[4] AN NK1.1+ CD4+8- SINGLE-POSITIVE THYMOCYTE SUBPOPULATION THAT EXPRESSES A HIGHLY SKEWED T-CELL ANTIGEN RECEPTOR-V-BETA FAMILY [J].

ARASE, H ;

ARASE, N ;

OGASAWARA, K ;

GOOD, RA ;

ONOE, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (14) :6506-6510

[5] NK1.1+ CD4+ CD8- THYMOCYTES WITH SPECIFIC LYMPHOKINE SECRETION [J].

ARASE, H ;

ARASE, N ;

NAKAGAWA, K ;

GOOD, RA ;

ONOE, K .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1993, 23 (01) :307-310

[6]

Azuma T, 2003, CANCER RES, V63, P4516

[7]

BALLAS ZK, 1990, J IMMUNOL, V145, P1039

[8] Dendritic cells and the control of immunity [J].

Banchereau, J ;

Steinman, RM .

NATURE, 1998, 392 (6673) :245-252

[9] Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection [J].

Baron, JL ;

Gardiner, L ;

Nishimura, S ;

Shinkai, K ;

Locksley, R ;

Ganem, D .

IMMUNITY, 2002, 16 (04) :583-594

[10] Association between alpha beta TCR(+)CD4(-)CD8(-) T-cell deficiency and IDDM in NOD/Lt mice [J].

Baxter, AG ;

Kinder, SJ ;

Hammond, KJL ;

Scollay, R ;

Godfrey, DI .

DIABETES, 1997, 46 (04) :572-582

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