NKT cells in tumor immunity: Opposing subsets define a new immunoregulatory axis

被引：97

作者：

Berzofsky, Jay A. ^{[1
]}

Terabe, Masaki ^{[1
]}

机构：

[1] NCI, Vaccine Branch, Bethesda, MD 20892 USA

来源：

JOURNAL OF IMMUNOLOGY | 2008年 / 180卷 / 06期

关键词：

D O I：

10.4049/jimmunol.180.6.3627

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

NKTcells are true Ag-specific T cells that also have innate properties and form a bridge between the innate and adaptive immune systems. Distinct NKT cell subsets play positive and negative regulatory roles and define a new immunoregulatory axis with broad implications for tumor immunity and other immunological and disease settings.

引用

收藏

页码：3627 / 3635

页数：9

相关论文

共 127 条

[41] Opinion - NKT cells: what's in a name? [J].

Godfrey, DI ;

MacDonald, HR ;

Kronenberg, M ;

Smyth, MJ ;

Van Kaer, L .

NATURE REVIEWS IMMUNOLOGY, 2004, 4 (03) :231-237

[42] Flow cytometric study of T cell development in NOD mice reveals a deficiency in alpha beta TCR(+)CD4(-)CD8(-) thymocytes [J].

Godfrey, DI ;

Kinder, SJ ;

Silvera, P ;

Baxter, AG .

JOURNAL OF AUTOIMMUNITY, 1997, 10 (03) :279-285

[43] Going both ways: immune regulation via CD1d-dependent NKT cells [J].

Godfrey, DI ;

Kronenberg, M .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (10) :1379-1388

[44] Early quantitative and functional deficiency of NK1(+)-like thymocytes in the NOD mouse [J].

Gombert, JM ;

Herbelin, A ;

TancredeBohin, E ;

Dy, M ;

Carnaud, C ;

Bach, JF .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1996, 26 (12) :2989-2998

[45] Murine CD1d-restricted T cell recognition of cellular lipids [J].

Gumperz, JE ;

Roy, C ;

Makowska, A ;

Lum, D ;

Sugita, M ;

Podrebarac, T ;

Koezuka, Y ;

Porcelli, SA ;

Cardell, S ;

Brenner, MB ;

Behar, SM .

IMMUNITY, 2000, 12 (02) :211-221

[46] Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining [J].

Gumperz, JE ;

Miyake, S ;

Yamamura, T ;

Brenner, MB .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (05) :625-636

[47] Type IINKT cell-mediated anergy induction in type INKT cells prevents inflammatory liver disease [J].

Halder, Ramesh C. ;

Aguilera, Carlos ;

Maricic, Igor ;

Kumar, Vipin .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (08) :2302-2312

[48] α/β-T cell receptor (TCR)+CD4-CD8- (NKT) thymocytes prevent insulin-dependent diabetes mellitus in nonobese diabetic (NOD)/Lt mice by the influence of interleukin (IL)-4 and/or IL-10 [J].

Hammond, KJL ;

Poulton, LD ;

Palmisano, LJ ;

Silveira, PA ;

Godfrey, DI ;

Baxter, AG .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (07) :1047-1056

[49] Alleviation of acute and chronic graft-versus-host disease in a murine model is associated with glucocerebroside-enhanced natural killer T lymphocyte plasticity [J].

Ilan, Yaron ;

Ohana, Meir ;

Pappo, Orit ;

Margalit, Maya ;

Lalazar, Gadi ;

Engelhardt, Dean ;

Rabbani, Elazar ;

Nagler, Arnon .

TRANSPLANTATION, 2007, 83 (04) :458-467

[50] A phase I study of α-galactosylceramide (KRN7000)-pulsed dendritic cells in patients with advanced and recurrent non-small cell lung cancer [J].

Ishikawa, A ;

Motohashi, S ;

Ishikawa, E ;

Fuchida, H ;

Higashino, K ;

Otsuji, M ;

Iizasa, T ;

Nakayama, T ;

Taniguchi, M ;

Fujisawa, T .

CLINICAL CANCER RESEARCH, 2005, 11 (05) :1910-1917

← 1 2 3 4 5 6 7 8 9 10 →