Trovafloxacin in combination with vancomycin against penicillin-resistant pneumococci in the rabbit meningitis model

被引：21

作者：

Rodoni, D

Hänni, F

Gerber, CM

Cottagnoud, M

Neftel, K

Täuber, MG

Cottagnoud, P

机构：

[1] Univ Bern, Inselspital, Dept Internal Med, CH-3010 Bern, Switzerland

[2] Univ Bern, Zieglerspital, Dept Internal Med, CH-3010 Bern, Switzerland

[3] Univ Bern, Inst Med Microbiol, CH-3010 Bern, Switzerland

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 04期

关键词：

D O I：

10.1128/AAC.43.4.963

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Trovafloxacin, a neu fluoroquinolone, produced bactericidal activity (-0.33 +/- 0.13 Delta log(10) CFU/ml . h; intravenously [i.v.] administered dose, 15 mg/kg) comparable to that of vancomycin (-0.39 +/- 0.18 Delta log(10) CFU/ml . h; i.v, administered dose, 20 mg/kg) in the treatment of experimental meningitis in rabbits due to a pneumococcal strain highly resistant to penicillin (MIC of penicillin G, 4 mu g/ml). The combination of both drugs significantly increased (P < 0.05) the killing rate (-0.60 +/- 0.23 Delta log(10) CFU/ml . h) compared to that produced by either monotherapy, These results were also confirmed in vitro.

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页码：963 / 965

页数：3

相关论文

共 18 条

[1] A critical evaluation of vancomycin for treatment of bacterial meningitis [J].

Ahmed, A .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1997, 16 (09) :895-903

[2] Penetration of trovafloxacin into cerebrospinal fluid in humans following intravenous infusion of alatrofloxacin [J].

Cutler, NR ;

Vincent, J ;

Jhee, SS ;

Teng, RL ;

Wardle, T ;

Lucas, G ;

Dogolo, LC ;

Sramek, JJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (06) :1298-1300

[3] EFFECT OF PROBENECID ON CEREBROSPINAL-FLUID CONCENTRATIONS OF PENICILLIN AND CEPHALOSPORIN DERIVATIVES [J].

DACEY, RG ;

SANDE, MA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1974, 6 (04) :437-441

[4] Bactericidal activity against intermediately cephalosporin-resistant Streptococcus pneumoniae in cerebrospinal fluid of children with bacterial meningitis treated with high doses of cefotaxime and vancomycin [J].

Doit, C ;

Barre, J ;

Cohen, R ;

Bonacorsi, S ;

Bourrillon, A ;

Bingen, EH .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (09) :2050-2052

[5] ORAL RIFAMPIN PLUS OFLOXACIN FOR TREATMENT OF STAPHYLOCOCCUS-INFECTED ORTHOPEDIC IMPLANTS [J].

DRANCOURT, M ;

STEIN, A ;

ARGENSON, JN ;

ZANNIER, A ;

CURVALE, G ;

RAOULT, D .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (06) :1214-1218

[6] INVITRO ACTIVITY OF CP-99,219, A NEW FLUOROQUINOLONE, AGAINST CLINICAL ISOLATES OF GRAM-POSITIVE BACTERIA [J].

ELIOPOULOS, GM ;

KLIMM, K ;

ELIOPOULOS, CT ;

FERRARO, MJ ;

MOELLERING, RC .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (02) :366-370

[7]

ELIOPOULOS GM, 1991, ANTIBIOTICS LAB MED, P330

[8] EVALUATION OF ANTIMICROBIAL REGIMENS FOR TREATMENT OF EXPERIMENTAL PENICILLIN-RESISTANT AND CEPHALOSPORIN-RESISTANT PNEUMOCOCCAL MENINGITIS [J].

FRIEDLAND, IR ;

PARIS, M ;

EHRETT, S ;

HICKEY, S ;

OLSEN, K ;

MCCRACKEN, GH .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (08) :1630-1636

[9] INVITRO ANTIMICROBIAL ACTIVITY OF CP-99,219, A NOVEL AZABICYCLO-NAPHTHYRIDONE [J].

GOODING, BB ;

JONES, RN .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (02) :349-353

[10] Trovafloxacin [J].

Haria, M ;

Lamb, HM .

DRUGS, 1997, 54 (03) :435-445