Nanoparticle fluorescence based technology for biological applications

被引：252

作者：

Chen, Wei ^{[1
]}

机构：

[1] Univ Texas Arlington, Dept Phys, Arlington, TX 76019 USA

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2008年 / 8卷 / 03期

关键词：

nanoparticles; quantum size confinement; fluorescence; upconversion; surface plasmon; water solubility; bioconjugation; energy transfer; photodynamic therapy; medical Imaging; cancer treatment;

D O I：

10.1166/jnn.2008.301

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Fluorescence is widely used in biological detection and imaging. The emerging luminescent nanoparticles or quantum dots provide a new type of biological agents that can improve these applications. The advantages of luminescent nanoparticles for biological applications include their high quantum yield, color availability, good photo-stability, large surface-to-volume ratio, surface functionality, and small size. In this review article, we first introduce quantum size confinement, photoluminescence and upconversion luminescence of nanoparticles, then describe the preparation and conjugation of water soluble nanoparticles and introduce the applications of luminescence nanoparticles for in vitro and in vivo imaging, fluorescence resonance energy based detection, and the applications of luminescence nanoparticles for photodynamic activation.

引用

页码：1019 / 1051

页数：33

共 196 条

[81]

Lakowicz J. R., 2006, PRINCIPLES FLUORESCE, DOI [10.1007/978-0-387-46312-4, DOI 10.1007/978-0-387-46312-4]

[82] Radiative decay engineering: Biophysical and biomedical applications [J].

Lakowicz, JR .

ANALYTICAL BIOCHEMISTRY, 2001, 298 (01) :1-24

[83] Photophysical properties of porphyrinoid sensitizers non-covalently bound to host molecules;: models for photodynamic therapy [J].

Lang, K ;

Mosinger, J ;

Wagnerová, DM .

COORDINATION CHEMISTRY REVIEWS, 2004, 248 (3-4) :321-350

[84]

Larson DR, 2003, SCIENCE, V300, P1434, DOI 10.1126/science.1083780

[85] Exciton fine structure in single CdSe nanorods -: art. no. 016803 [J].

Le Thomas, N ;

Herz, E ;

Schöps, O ;

Woggon, U ;

Artemyev, MV .

PHYSICAL REVIEW LETTERS, 2005, 94 (01)

[86]

Leung Alexander K C, 2005, J Natl Med Assoc, V97, P1708

[87] Quantum-dot aptamer beacons for the detection of proteins [J].

Levy, M ;

Cater, SF ;

Ellington, AD .

CHEMBIOCHEM, 2005, 6 (12) :2163-2166

[88] Molecular aptamer beacons for real-time protein recognition [J].

Li, JWJ ;

Fang, XH ;

Tan, WH .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 292 (01) :31-40

[89]

Li JWJ, 2000, ANGEW CHEM INT EDIT, V39, P1049, DOI 10.1002/(SICI)1521-3773(20000317)39:6<1049::AID-ANIE1049>3.0.CO

[90]

2-2

← 4 5 6 7 8 9 10 11 12 13 →