Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-cadherin trafficking from recycling endosomes to the plasma membrane

被引：221

作者：

Langevin, J

Morgan, MJ

Rossé, C

Racine, V

Sibarita, JB

Aresta, S

Murthy, M

Schwarz, T

Camonis, J

Bellaïche, Y

机构：

[1] Inst Curie, UMR 144, F-75236 Paris, France

[2] Inst Curie, INSERM, U528, F-75236 Paris, France

[3] Inst Curie, UMR 144, F-75236 Paris, France

[4] Hybrigen, F-75014 Paris, France

[5] Harvard Univ, Sch Med, Childrens Hosp, Div Neurosci, Boston, MA 02115 USA

来源：

DEVELOPMENTAL CELL | 2005年 / 9卷 / 03期

关键词：

D O I：

10.1016/j.devcel.2005.07.013

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The E-Cadherin-catenin complex plays a critical role in epithelial cell-cell adhesion, polarization, and morphogenesis. Here, we have analyzed the mechanism of Drosophila E-Cadherin (DE-Cad) localization. Loss of function of the Drosophila exocyst components sec5, sec6, and sec15 in epithelial cells results in DE-Cad accumulation in an enlarged Rab11 recycling endosomal compartment and inhibits DE-Cad delivery to the membrane. Furthermore, Rab11 and Armadillo interact with the exocyst components Sec15 and Sec10, respectively. Our results support a model whereby the exocyst regulates DE-Cadherin trafficking, from recycling endosomes to sites on the epithelial cell membrane where Armadillo is located.

引用

收藏

页码：365 / 376

页数：12

相关论文

共 54 条

[1] Drosophila Sec10 is required for hormone secretion but not general exocytosis or neurotransmission [J].

Andrews, HK ;

Zhang, YQ ;

Trotta, N ;

Broadie, K .

TRAFFIC, 2002, 3 (12) :906-921

[2] Recycling endosomes can serve as intermediates during transport from the Golgi to the plasma membrane of MDCK cells [J].

Ang, AL ;

Taguchi, T ;

Francis, S ;

Fölsch, H ;

Murrells, LJ ;

Pypaert, M ;

Warren, G ;

Mellman, I .

JOURNAL OF CELL BIOLOGY, 2004, 167 (03) :531-543

[3] The planar cell polarity protein Strabismus promotes Pins anterior localization during asymmetric division of sensory organ precursor cells in Drosophila [J].

Bellaïche, Y ;

Beaudoin-Massiani, O ;

Stüttem, I ;

Schweisguth, F .

DEVELOPMENT, 2004, 131 (02) :469-478

[4] Frizzled regulates localization of cell-fate determinants and mitotic spindle rotation during asymmetric cell division [J].

Bellaïche, Y ;

Gho, M ;

Kaltschmidt, JA ;

Brand, AH ;

Schweisguth, F .

NATURE CELL BIOLOGY, 2001, 3 (01) :50-57

[5] Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells [J].

Beronja, S ;

Laprise, P ;

Papoulas, O ;

Pellikka, M ;

Sisson, J ;

Tepass, U .

JOURNAL OF CELL BIOLOGY, 2005, 169 (04) :635-646

[6] Epithelial polarity and proliferation control:: links from the Drosophila neoplastic tumor suppressors [J].

Bilder, D .

GENES & DEVELOPMENT, 2004, 18 (16) :1909-1925

[7] Vesicles carry most exocyst subunits to exocytic sites marked by the remaining two subunits, Sec3p and Exo70p [J].

Boyd, C ;

Hughes, T ;

Pypaert, M ;

Novick, P .

JOURNAL OF CELL BIOLOGY, 2004, 167 (05) :889-901

[8] Coupling assembly of the E-cadherin/β-catenin complex to efficient endoplasmic reticulum exit and basal-lateral membrane targeting of E-cadherin in polarized MDCK cells [J].

Chen, YT ;

Stewart, DB ;

Nelson, WJ .

JOURNAL OF CELL BIOLOGY, 1999, 144 (04) :687-699

[9] Armadillo is required for adherens junction assembly, cell polarity, and morphogenesis during Drosophila embryogenesis [J].

Cox, RT ;

Kirkpatrick, C ;

Peifer, M .

JOURNAL OF CELL BIOLOGY, 1996, 134 (01) :133-148

[10]

Dollar G, 2002, DEVELOPMENT, V129, P517

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