Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-cadherin trafficking from recycling endosomes to the plasma membrane

被引：221

作者：

Langevin, J

Morgan, MJ

Rossé, C

Racine, V

Sibarita, JB

Aresta, S

Murthy, M

Schwarz, T

Camonis, J

Bellaïche, Y

机构：

[1] Inst Curie, UMR 144, F-75236 Paris, France

[2] Inst Curie, INSERM, U528, F-75236 Paris, France

[3] Inst Curie, UMR 144, F-75236 Paris, France

[4] Hybrigen, F-75014 Paris, France

[5] Harvard Univ, Sch Med, Childrens Hosp, Div Neurosci, Boston, MA 02115 USA

来源：

DEVELOPMENTAL CELL | 2005年 / 9卷 / 03期

关键词：

D O I：

10.1016/j.devcel.2005.07.013

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The E-Cadherin-catenin complex plays a critical role in epithelial cell-cell adhesion, polarization, and morphogenesis. Here, we have analyzed the mechanism of Drosophila E-Cadherin (DE-Cad) localization. Loss of function of the Drosophila exocyst components sec5, sec6, and sec15 in epithelial cells results in DE-Cad accumulation in an enlarged Rab11 recycling endosomal compartment and inhibits DE-Cad delivery to the membrane. Furthermore, Rab11 and Armadillo interact with the exocyst components Sec15 and Sec10, respectively. Our results support a model whereby the exocyst regulates DE-Cadherin trafficking, from recycling endosomes to sites on the epithelial cell membrane where Armadillo is located.

引用

页码：365 / 376

页数：12

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