Resolution of non-protein amino acids via microbial protease-catalyzed ester hydrolysis: Marked enhancement of enantioselectivity by the use of esters with longer alkyl chains and at low temperature

被引：38

作者：

Miyazawa, T

Minowa, H

Miyamoto, T

Imagawa, K

Yanagihara, R

Yamada, T

机构：

[1] Department of Chemistry, Faculty of Science, Konan University, Kobe 658, Higashinada-ku

来源：

TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 03期

关键词：

D O I：

10.1016/S0957-4166(97)00002-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

In the microbial protease-catalyzed hydrolysis of amino acid esters with the free alpha-amino group, the enantioselectivity can be enhanced greatly by employing esters with longer alkyl chains such as the isobutyl ester instead of the conventional methyl ester and by conducting the reaction at low temperature. (C) 1997 Elsevier Science Ltd. All rights reserved.

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页码：367 / 370

页数：4

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