Efficient nucleophilic substitution reactions of highly functionalized allyl halides in ionic liquid media

被引：31

作者：

Kotti, SRSS ^{[1
]}

Xu, X ^{[1
]}

Li, GG ^{[1
]}

Headley, AD ^{[1
]}

机构：

[1] Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 07期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

alpha; beta-unsaturated ketone; ionic liquid; S(N)2 reaction; halides;

D O I：

10.1016/j.tetlet.2003.12.051

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Nucleophilic substitution reactions of highly functionalized allyl halides with three anions, N-3(-), AcO-, and PhSO2-, in ionic liquid media were conducted. The ionic liquid, [Bmim][BF4], was found to be superior to classical organic solvents to give higher yields and faster reaction rates. The resulting products belong to multifunctionalized trisubstituted alpha,beta-unsaturated ketones, which are useful building blocks for organic synthesis. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：1427 / 1431

页数：5

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