A minimal protein folding model to measure hydrophobic and CH-π effects on interactions between nonpolar surfaces in water

被引：82

作者：

Bhayana, Brijesh ^{[1
]}

Wilcox, Craig S. ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 36期

关键词：

conformation analysis; Gibbs energy hydrophobic; interactions; protein folding; solvent effects;

D O I：

10.1002/anie.200700932

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) In the balance: A synthetic molecule that exhibits two-state folding behavior in water is described. Quantitative experiments reveal that the microscopic hydrophobic effect is similar in magnitude to the CH-π, interaction. These forces may therefore be equally important in the folding of aromatic-rich regions of proteins. The method allows a new approach to the direct measurement of excess surface energy associated with nonpolar surfaces. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：6833 / 6836

页数：4

共 78 条

[11] THROUGH-SPACE POLAR-PI EFFECTS ON THE ACIDITY AND HYDROGEN-BONDING CAPACITY OF CARBOXYLIC-ACIDS [J].

CHEN, CT ;

SIEGEL, JS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (13) :5959-5960

[12] Balancing solvation and intramolecular interactions: Toward a consistent generalized born force field [J].

Chen, JH ;

Im, WP ;

Brooks, CL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (11) :3728-3736

[13] An efficient and scalable synthesis of methyl 3-hydroxymethylbenzoate [J].

Chen, MH ;

Davidson, JG ;

Freisler, JT ;

Iakovleva, E ;

Magano, J .

ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 2000, 32 (04) :381-384

[14] Benzene dimer: A good model for pi-pi interactions in proteins? A comparison between the benzene and the toluene dimers in the cas phase and in an aqueous solution [J].

Chipot, C ;

Jaffe, R ;

Maigret, B ;

Pearlman, DA ;

Kollman, PA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (45) :11217-11224

[15] IODINE-X(O, N, S) INTERMOLECULAR CONTACTS - MODELS OF THYROID-HORMONE PROTEIN-BINDING INTERACTIONS USING INFORMATION FROM THE CAMBRIDGE CRYSTALLOGRAPHIC DATA FILES [J].

CODY, V ;

MURRAYRUST, P .

JOURNAL OF MOLECULAR STRUCTURE, 1984, 112 (3-4) :189-199

[16]

CONNORS CA, 1987, BINDING CONSTANTS

[17] A topological analysis of electron density in cation-π complexes [J].

Cubero, E ;

Orozco, M ;

Luque, FJ .

JOURNAL OF PHYSICAL CHEMISTRY A, 1999, 103 (02) :315-321

[18]

Diederich F., 2004, ANGEW CHEM, V116, P5166

[19] ACETYLCHOLINE BINDING BY A SYNTHETIC RECEPTOR - IMPLICATIONS FOR BIOLOGICAL RECOGNITION [J].

DOUGHERTY, DA ;

STAUFFER, DA .

SCIENCE, 1990, 250 (4987) :1558-1560

[20] SUBSTITUENT EFFECT ON THE ENTHALPIES OF FORMATION OF CH-PI COMPLEXES OF AROMATIC PI-BASES [J].

EHAMA, R ;

TSUSHIMA, M ;

YUZURI, T ;

SUEZAWA, H ;

SAKAKIBARA, K ;

HIROTA, M .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1993, 66 (03) :814-818

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