Internalins: a complex family of leucine-rich repeat-containing proteins in Listeria monocytogenes

被引:213
作者
Bierne, H. [1 ]
Sabet, C. [1 ]
Personnic, N. [1 ]
Cossart, R. [1 ]
机构
[1] Inst Pasteur, Unite Interact Bacteries Cellules, INSERM U604, INRA USC2020, F-75015 Paris, France
关键词
leucine-rich repeat; pathogenicity; surface proteins; virulence factors; invasins; PRFA-REGULATED GENE; HOST-CELL INVASION; SURFACE-PROTEINS; COMPARATIVE GENOMICS; LRR PROTEINS; VIRULENCE; INIB; IDENTIFICATION; EXPRESSION; DOMAIN;
D O I
10.1016/j.micinf.2007.05.003
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The Listeria monocytogenes genome includes a large family of proteins harbouring leucine-rich repeats known as internalins (Inl). The generation of novel mutants and comparative analysis of Inl variability among Listeria and other bacterial genomes suggest that beyond the extensively- studied invasins, InlA and InlB, additional internalins also play important functions in the infectious process. (C) 2007 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:1156 / 1166
页数:11
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