Cinchona alkaloid induced chiral discrimination for the determination of the enantiomeric composition of α-trifluoromethylated-hydroxyl compounds by 19F NMR spectroscopy

被引：29

作者：

Abid, M ^{[1
]}

Török, B ^{[1
]}

机构：

[1] Michigan Technol Univ, Dept Chem, Houghton, MI 49931 USA

来源：

TETRAHEDRON-ASYMMETRY | 2005年 / 16卷 / 08期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/j.tetasy.2005.02.034

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The determination of the enantiomeric composition of alpha-trifluoromethylated-hydroxyl compounds using cinchona alkaloids as chiral selectors is described. The interaction between the alkaloid and trifluoromethylated-hydroxyl compounds converted the enantiotopic nuclei to diastereotopic nuclei observed by F-19 NMR spectroscopy. A wide variety of target molecules have been studied to highlight the broad applicability of the method. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1547 / 1555

页数：9

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